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Serum Levels of IGF-I, HGF,
TGFβ1, bFGF and VEGF in Thyroid Gland Tumors
D. VESELÝ1, J. ASTL1,2, P.
LAŠTŮVKA1, P. MATUCHA3, I. ŠTERZL3,4,
J. BETKA1,2
1Department of Otorhinolaryngology, Head and Neck
Surgery, the First Medical Faculty of the Charles University,
University Hospital Motol, 2ENT Department,
Postgraduate School of Medicine, 3Institute of
Endocrinology, 4Institute of Immunology and
Microbiology, First Medical Faculty of Charles University,
General University Hospital, Prague, Czech Republic
Received April 4, 2002
Accepted January 10, 2003
Summary
IGF-I, HGF, TGFβ1, bFGF
and VEGF are involved in the pathogenesis of thyroid gland tumors and their
growth. We decided to find whether changes in the production of these cytokines
by thyroid tumor cells are reflected by changes of their peripheral blood. Using
ELISA kits, we measured the concentrations of growth factors in the peripheral
blood serum in 28 patients with thyroid gland tumors (14 adenomas, 14 papillary
carcinomas) and compared these concentrations with those in healthy people. We
found significantly lower serum levels of IGF-I in patients with thyroid adenoma
compared to the healthy population. Serum levels of HGF and bFGF were
significantly higher in patients with thyroid adenoma and papillary carcinoma
compared with those in healthy subjects. Serum concentrations of TGFβ1 and VEGF
were not significantly different in any groups of investigated subjects. Changes
in the production of these cytokines by thyroid gland tumor cells are reflected
in their peripheral blood levels, but these levels also depend on a number of
other physiological and pathological processes in the organism. However,
significant differences of HGF and bFGF serum levels can be explained by their
very high production by thyroid tumor cells and by their strong effect on the
follicular and endothelial cell proliferation.
Key words
Growth factors • Thyroid gland • Thyroid adenoma • Thyroid
papillary carcinoma • Angiogenesis
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