Cough, Expiration and Aspiration Reflexes
following Kainic Acid Lesions to the Pontine Respiratory Group in
Anesthetized Cats
I. POLIAČEK, J. JAKUŠ, A. STRÁNSKY, H. BARÁNI, E. HALAŠOVÁ1,
Z. TOMORI2
Department of Biophysics, 1Department of Biology, Comenius
University, Jessenius Faculty of Medicine, Martin and 2Department
of Pathophysiology, Faculty of Medicine, Šafárik University, Košice,
Slovak Republic
Received March 31, 2003
Accepted May 16, 2003
Summary
The importance of neurons in the pontine respiratory group for the
generation of cough, expiration, and aspiration reflexes was studied on
non-decerebrate spontaneously breathing cats under pentobarbitone
anesthesia. The dysfunction of neurons in the pontine respiratory group
produced by bilateral microinjection of kainic acid (neurotoxin) regularly
abolished the cough reflexes evoked by mechanical stimulation of both the
tracheobronchial and the laryngopharyngeal mucous membranes and the
expiration reflex mechanically induced from the glottis. The aspiration
reflex elicited by similar stimulation of the nasopharyngeal region
persisted in 73 % of tests, however, with a reduced intensity compared to
the pre-lesion conditions. The pontine respiratory group seems to be an
important source of the facilitatory inputs to the brainstem circuitries
that mediate cough, expiration, and aspiration reflexes. Our results
indicate the significant role of pons in the multilevel organization of
brainstem networks in central integration of the aforementioned reflexes.
Key words
Pontine respiratoy group • Cough • Defensive airway reflexes • Kainic acid
lesion • Cat
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