SHORT COMMUNICATION
Phospholipid Composition of
Myocardium in Children with Normoxemic and Hypoxemic Congenital
Heart Diseases
B. HAMPLOVÁ1, V. PELOUCH2, O. NOVÁKOVÁ1,
J. ŠKOVRÁNEK3,
B. HUČÍN3, F. NOVÁK4
1Department of Animal Physiology and Developmental
Biology, 4Department of Biochemistry, Faculty of
Science, 2Second Faculty of Medicine, Charles
University, 3Cardiocenter of Faculty Hospital Motol,
Prague, Czech Republic
Received May 13, 2003
Accepted October 24, 2003
Summary
Samples of myocardial tissue were obtained during cardiac
surgery from children operated for different types of normoxemic
and hypoxemic congenital heart diseases. The phospholipid
composition was analyzed by thin layer chromatography. The
concentration of total phospholipids (PL), phosphatidylcholine
and phosphatidylethanolamine (PE) was found lower in atrial
tissue of both normoxemic and hypoxemic groups in comparison
with the ventricles. When comparing the difference between
hypoxemic and normoxemic defects, hypoxemia was found to
increase the concentration of total PL, PE and
phosphatidylserine in ventricles and total PL and PE in the
atria. The increased level of particular phospholipid species
may represent adaptive mechanisms to hypoxemia in children with
congenital heart diseases.
Key words
Phospholipids • Human myocardium • Congenital heart disease •
Ventricle • Atrium
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