Gender Differences in Tumor
Necrosis Factor α and Leptin Secretion from Subcutaneous and
Visceral Fat Tissue
M. OREL, R. LICHNOVSKÁ, S. GWOZDZIEWICZOVÁ, N. ZLÁMALOVÁ1,
I. KLEMENTA1, A. MERKUNOVÁ2, J. HŘEBÍČEK
Institute of Physiology, 1First Department of
Surgery, Faculty of Medicine, Palacký University, Olomouc, and
2Institute of Social Studies, University of Hradec
Králové, Czech Republic
Received July 24, 2003
Accepted October 28, 2003
Summary
Tumor necrosis factor α (TNFα) and leptin concentrations were
determined in the abdominal subcutaneous and visceral (omental)
adipose tissue of patients undergoing elective open-abdominal
surgery and compared with their body mass index. The
concentration of leptin did not differ significantly between
women and men, being high in subcutaneous fat tissue and low in
visceral fat tissue. TNFα concentration in subcutaneous fat
tissue was approximately the same in both genders, but it was
significantly lower in visceral fat tissue of women and
unchanged in visceral fat tissue of men. A significant
correlation between BMI and leptin was found in the two fat
tissue compartments of both genders, but the correlation between
BMI and TNFα was found only in subcutaneous fat tissue of women.
Key words
Tumor necrosis factor α • Leptin • Subcutaneous fat tissue •
Visceral fat tissue
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