Physiol. Res. 53: 629-634, 2004


Renal Concentrating Capacity is Linked to Blood Pressure in Children with Autosomal Dominant Polycystic Kidney Disease

T. SEEMAN, J. DUŠEK, K. VONDRÁK, K. BLÁHOVÁ, E. ŠIMKOVÁ, J. KREISINGER, P. DVOŘÁK, M. KYNČL1, Z. HŘÍBAL1, J. JANDA

First Department of Pediatrics and 1Department of Radiology, University Hospital Motol, Prague, Czech Republic

Received September 15, 2003
Accepted February 19, 2004


Summary
Impaired glomerular filtration rate (GFR) is a risk factor for the development of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD). However, markers of tubular function were not tested whether they are linked to hypertension or blood pressure (BP) level. The aim of our study was to investigate the relationship between renal concentrating capacity and BP in children with ADPKD. Fifty-three children (mean age 11.84.4 years) were investigated. Standardized renal concentrating capacity test was performed after nasal drop application of desmopressin, BP was measured by ambulatory BP monitoring (ABPM). Renal concentrating capacity was decreased in 58 % of children. The prevalence of hypertension was significantly higher in children with decreased renal concentrating capacity (35 %) than in children with normal renal concentrating capacity (5 %) (p0.05). Significant negative correlations were found between renal concentrating capacity, ambulatory BP and number of renal cysts (r = –0.29 to
–0.39, p0.05 to p0.01). In conclusion, the concentrating capacity is decreased in about half of the patients and is linked to BP. Decreased renal concentrating capacity should be considered as an early marker of functional impairment in ADPKD and a further risk factor for hypertension.


Key words
Renal concentrating capacity test • Autosomal dominant polycystic kidney disease • Blood pressure • Hypertension • Children


© 2004 by the Institute of Physiology, Czech Academy of Sciences