RAPID COMMUNICATION
Apolipoprotein AV Variants
Do Not Affect C-Reactive Protein Levels in Caucasian Males
J. A. HUBÁČEK1,3, Z. ŠKODOVÁ2,
V. LÁNSKÁ1, P. STÁVEK1, V. ADÁMKOVÁ2,
R. POLEDNE1,3
1Center for Experimental Medicine and 2Department
of Preventive Cardiology, Institute for Clinical and
Experimental Medicine and 3Cardiovascular Research
Center, Prague, Czech Republic
Received January 1, 2005
Accepted April 13, 2005
On-line available April 26, 2005
Summary
The important role of APOAV gene variants in determination of
plasma triglyceride levels has been shown in many population
studies. Recently, an influence of APOAV T-1131>C polymorphism
on C-reactive protein (CRP) in young Korean males has been
reported. We have therefore analyzed a putative association
between T-1131>C, Ser19>Trp and Val153>Met APOAV variants (PCR
and restriction analysis) and CRP concentrations in 1119
Caucasian males, aged between 28 and 67 years (49.2±10.8 years).
The frequency of C allele carriers was lower in Caucasians than
in Koreans (15.5 % vs. 46.2 %). CRP levels did not differ
between T/T homozygotes (n=946, 1.61±2.05 mg/l) and carriers of
the C allele (n=173, 1.67±1.95 mg/l). Thus, in contrast to
Korean males, T-1131>C APOAV variant has no effect on plasma
concentrations of CRP in a large group of Caucasian males. Other
APOAV variants (Ser19>Trp and Val153>Met) did not also influence
plasma concentrations of CRP. APOAV variants are unlikely to be
an important genetic determinant of plasma CRP concentrations in
Caucasian males.
Key words
Apolipoprotein AV • Polymorphism • Genetics • Triglycerides •
Myocardial infarction • CRP
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