Antioxidant Vitamin Levels Do
Not Exhibit Negative Correlation with the Extent of Acute
Myocardial Infarction
V. MUŽÁKOVÁ1, P. VOJTÍŠEK2,
M. MELOUN3, R. VAŇKOVÁ4, T. ROUŠAR1,
Z. ČERVINKOVÁ5
1Department of Biological and Biochemical Sciences,
Faculty of Chemical Technology, University of Pardubice, 2Department
of Cardiology, Hospital of Pardubice, 3Department of
Analytical Chemistry, Faculty of Chemical Technology, University
of Pardubice, 4Institute of Experimental Botany,
Academy of Sciences of the Czech Republic, Prague and 5Department
of Physiology, Faculty of Medicine, Charles University, Hradec
Králové, Czech Republic
Received August 29, 2004
Accepted December 15, 2004
On-line available February 16, 2005
Summary
Serum levels of vitamin E (VE), β-carotene (BC) and vitamin C
(VC) were determined in 50 patients with the first acute
myocardial infarction (AMI) before starting thrombolytical
treatment. VE and BC were determined by HPLC, VC
spectrophotometrically. The reperfused patients were divided
according to vitamin concentrations into four groups. The lowest
quartile was compared with the rest of the studied population
(VE: group with high (H) > 15.6 μM > group with low (L), BC: H >
0.07 μM > L, VC: H > 25 μM > L) in the following parameters:
extent of myocardial damage (area under the curves of troponin
I, CK-MB during 48 h), arrhythmia and congestive heart failure
occurrence, size of ejection fraction, positivity of ventricular
late potentials. No significant differences between groups H and
L for either VE, BC or VC were found (P±0.05).
As no correlation between serum concentrations of vitamins E, C
and β-carotene and the extent and clinical course of AMI was
found, the actual vitamin concentrations may be important for
prevention of ischemic heart a disease, but they do not play a
decisive role in the acute phase of myocardial infarction in
humans.
Key words
Antioxidant vitamins • α-Tocopherol • β-Carotene • Ascorbic acid
• Myocardial infarction.
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