Biological Half-life of
Bromide in the Rat Depends Primarily
on the Magnitude of Sodium Intake
S. PAVELKA1,2, A. BABICKÝ3,
M. VOBECKÝ3
1Institute of Physiology, Academy of Sciences of the
Czech Republic, Prague, 2Department of Biochemistry,
Faculty of Science, Masaryk University, Brno and 3Institute
of Analytical Chemistry, Academy of Sciences of the Czech
Republic, Prague, Czech Republic
Received August 23, 2004
Accepted January 21, 2005
On-line available February 16, 2005
Summary
The parallel course of the excretion rates of bromide and sodium
ions was demonstrated in adult male and female rats administered
simultaneously with potassium 82Br-bromide and 24Na-sodium
chloride. The animals were exposed to various intakes of sodium
ions accompanied with five different anions: Br-, Cl-, HCO3-,
ClO4-, and SCN-. Regardless of the anion
accompanying the sodium ion, the excretion rates of 82Br-
and 24Na+ ions were proportional to the magnitude of
sodium intake in the animals. Hence, we have proved our
hypothesis that the biological half-life of bromide depends on
the magnitude of sodium intake rather than on the intake of
chloride.
Key words
Biological half-life • Bromide • Chloride • Sodium • Rat
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