The Influence of
Very-Low-Calorie Diet on Serum Leptin, Soluble Leptin Receptor,
Adiponectin and Resistin Levels in Obese Women
K. ANDERLOVÁ1, J. KŘEMEN1,
R. DOLEŽALOVÁ1, J. HOUSOVÁ J1,
D. HALUZÍKOVÁ2, M. KUNEŠOVÁ3, M. HALUZÍK1
1Third Department of Medicine and 2Department
of Sports Medicine, First Faculty of Medicine, Charles
University, and 3Institute of Endocrinology, Prague,
Czech Republic
Received March 3, 2005
Accepted July 18, 2005
On-line available August 5, 2005
Summary
The aim of our study was to determine whether adipocyte-derived
hormones leptin, adiponectin and resistin contribute to the
improvement of insulin sensitivity after very-low calorie diet
(VLCD). Therefore, serum levels of these hormones were measured
in fourteen obese females before and after three weeks VLCD and
in seventeen age- and sex-matched healthy controls. Body mass
index, HOMA index, serum insulin and leptin levels in obese
women before VLCD were significantly higher than in control
group (BMI 48.01±2.02 vs. 21.38±0.42 kg/m2, HOMA 10.72±2.03 vs.
4.69±0.42, insulin 38.63±5.10 vs. 18.76±1.90 μIU/ml, leptin
77.87±8.98 vs. 8.82±1.52 ng/ml). In contrast, serum adiponectin
and soluble leptin receptors levels were significantly lower in
obese women before VLCD than in the control group. No
differences were found in serum glucose and resistin levels
between the obese group before VLCD and the control group. VLCD
significantly decreased BMI, HOMA index, serum glucose, insulin
and leptin levels and increased soluble leptin receptor levels.
The changes in serum adiponectin and resistin levels in obese
women after VLCD did not reach statistical significance. We
conclude that leptin and soluble leptin receptor levels were
affected by VLCD while adiponectin and resistin concentrations
were not. Therefore, other mechanisms rather than changes in the
endocrine function of the adipose tissue are probably involved
in the VLCD-induced improvement of insulin sensitivity.
Key words
Obesity • Insulin sensitivity • Very-low-calorie diet • Leptin •
Adiponectin • Resistin
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