Effect of Cardiac Lymph Flow
Obstruction on Cardiac Collagen Synthesis and Interstitial
Fibrosis
D. KONG, X. KONG, L. WANG1
Department of Cardiology, Liaocheng People’s Hospital, Liaocheng
City, Shandong Province, the People’s Republic of China, and
1School of Biomedical Sciences, Charles Sturt
University, Wagga Wagga, NSW, Australia
Received September 11, 2004
Accepted May 24, 2005
On-line available August 5, 2005
Summary
The effect of chronic cardiac lymphatic obstruction on the
myocardial synthesis of collagen type I and III was investigated
in a rabbit model. In the lymphatic obstruction group (n=16),
plasma C-terminal propeptide type I procollagen (PICP) and
N-terminal propeptide type III procollagen (PIIINP) were
elevated at 7, 14 and 30 days after the operation (p<0.05). The
elevated PICP and PIIINP returned to the pre-operation values 60
days after the operation. The myocardial expression of collagen
type I and III mRNA were also enhanced in the lymphatic flow
obstruction group. Plasma PICP, PIIINP and myocardial collagen
type I and III mRNA remained unchanged in the control group
(n=16). We concluded that chronic obstruction of cardiac lymph
flow leads to enhanced myocardial collagen synthesis in rabbits.
The enhanced collagen synthesis starts within seven days after
lymphatic obstruction and subsides after 60 days.
Key words
Cardiac lymph flow • Collagen • mRNA • Rabbits
|