Oxidized Low-Density Lipoprotein (Oxidized LDL) and the Risk of Preeclampsia

C. QIU¹, T. T. T. PHUNG², S. VADACHKORIA¹, M. MUY-RIVERA¹, S. E. SANCHEZ³, M. A. WILLIAMS<sup>1,2

1</sup>Center for Perinatal Studies, Swedish Medical Center, ²Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, USA, ³Ministry of Health, Lima, Peru

Received date June 8, 2005
Accepted date November 15, 2005
On-line available December 12, 2005



Summary
Oxidative stress plays an important role in the pathophysiology of preeclampsia. In a case-control study of 99 women with preeclampsia and 99 controls, we assessed maternal plasma oxidized low-density lipoprotein (oxidized LDL) in relation to preeclampsia risk. Logistic regression procedures were used to derive odds ratios (OR) and 95 % confidence intervals (CI). Plasma oxidized LDL was determined using enzyme immunoassay. Maternal plasma oxidized LDL was significantly positively correlated with lipids in both cases and controls. After adjusting for nulliparity, pre-pregnancy body mass index, physical inactivity, family history of chronic hypertension and plasma vitamin C concentrations, women who had elevated oxidized LDL concentrations (50 U/l) experienced a 2.9-fold increased risk of preeclampsia when compared with women having lower oxidized LDL concentrations (95 % CI 1.4-5.9). The risk of preeclampsia was markedly increased in women who had both elevated oxidized LDL and elevated triglyceride concentrations (OR=8.9, 95 % CI 3.1-26.2). Women with both elevated oxidized LDL and low vitamin C concentrations experienced a 9.8-fold increased risk of preeclampsia (95 % CI 3.0-32.2). Our results confirm the role of oxidative stress in the pathogenesis of preeclampsia. Prospective studies are needed to determine if elevated oxidized LDL concentrations can predict the occurrence of preeclampsia.


Key words
Oxidized LDL • Preeclampsia • Risk factors • Lipids • Vitamin C