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Welcome to the homepage of the Laboratory of Regulation of Gene Expression at the Institute of Microbiology ASCR in golden Prague at the heart of the Czech Republic.

Our laboratory, established in June 2006, investigates a basic concept of translation and various aspects of its regulation. The studies combine the use of budding yeast Saccharomyces cerevisiae and mammalian cells lines and employ tools of molecular and structural biology, biochemistry and genetics.

Our laboratory is supported by the world-renowned funding bodies such as the Wellcome Trust and Howard Hughes Medical Institute as well as by the prestigious Centre of Excellence grant from the Czech Grant Agency.

Enjoy exploring us!

There are currently no open positions in our laboratory.

NEWS AS OF Jan 31st, 2018
Last year was captured with a spray of publications in top journals: two comprehensive reviews, one on "all embracing" eIF3 in Nucleic Acids Research and the other "Please do not recycle!" on reinitiation (written by Slavka) in FEMS Microbiology Reviews, and one Molecular Cell paper of Maria Hatzoglou, Ivan Topisirovic and Ola Larsson, to which we contributed with our eIFs expertise. As far as this year is concerned, Petra and Jakub are almost done with their manuscripts, and there should be more from Susan (hopefully :) who has recently joined our collaborating lab of Thomas Preiss in Australia as a post-doc ... the best of luck! We have hired a new post-doc from Hungary, Farkash, starting in April 2018. Vladka's defence of her PhD work is behind the door - Feb 28th! Pasha followed by Jakub passed their state exams and now have to write up their thesis to get ready for the PhD defence. Petra has received her first real funding support - "mobility award" - and spent the first 3-months out of total six in the lab of our collaborator Olivier Namy in Paris.

Besides the generous Wellcome Trust support ending in June 2018, our research is supported by the highly prestigious Centre of Excellence Grant from the Czech Grant Agency and two other "GACR" grants. Our success rate with GACR thus remains at wonderful 100%!

Pasha got very recently married to Asha who should arrive to the Czech Republic in 2-3 months to break his loneliness :o) We are all very saddened by the loss of Prof. Drahos to Mr. Zeman in our presidential elections!!! It is a democracy, sure, but at the same time it is a real shame to be led by this unscrupulous, mean individual... BTW, this winter alternating heavy snow storms with heavy "tropical" rains during which everything melts sucks too ;o)

EMBO Workshop: Viral RNA: Structure, Function and Targeting - EMBL Heidelberg, March 5 - 7, 2007 EMBO Workshop: Viral RNA: Structure, Function and Targeting - EMBL Heidelberg, March 5 - 7, 2007