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Welcome to the homepage of the Laboratory of Regulation of Gene Expression at the Institute of Microbiology ASCR in golden Prague at the heart of the Czech Republic.

Our laboratory, established in June 2006, investigates a basic concept of translation and various aspects of its regulation. The studies combine the use of budding yeast Saccharomyces cerevisiae and mammalian cells lines and employ tools of molecular and structural biology, biochemistry and genetics.

Our laboratory is supported by the world-renowned funding bodies such as the Wellcome Trust and Howard Hughes Medical Institute as well as by the prestigious Centre of Excellence grant from the Czech Grant Agency.

Enjoy exploring us!

We seek highly motivated and skillful post-doc and Ph.D. and diploma students to start working with us in at the onset of 2018 - for details click here ***. If interested, please send your motivation letter as well as your CV to Leos @.

NEWS AS OF Nov 6, 2017
This year began with the Nucleic Acids Research paper from Pasha - extremely hard work that took him and Vanda nearly 8 years from the initial idea to completion ... congratulations! Then we followed with two RNA biol. articles, commentary in eLife, and a comprehensive review on "all embracing" eIF3 in Nucleic Acids Research, which will be hopefully soon joined by a similarly comprehensive review on reinitiation (written by Slavka) in FEMS Microbiological reviews. We also contributed to a nice story of Maria Hatzoglou, Ivan Topisirovic and Ola Larsson in Molecular Cell. Petra and Jakub are almost done with their manuscripts. Anicka and Susan received the shared Award for the 2nd. best publication published at our institute in 2016 for their NAR 2016 paper! Susan has recently joined our collaborating lab of Thomas Preiss in Australia as a post-doc ... the best of luck! Zuzka Pavlikova from Slovakia and Terezie Prilepskaja have just started their Ph.D. studies with us. Pasha passed the state exam and, together with Vladka, their are getting ready for their PhD defence (Jakub is the next runner up in this race :) Petra has received her first real funding support - "mobility award" - and went for a 6-months long post-doc to Olivier Namy's lab in Paris :)

Besides the generous Wellcome Trust support that will regretfully end soon with no option to renew (June 2018), our group together with 6 other young groups in the Czech Republic still lives from a highly prestigious Centre of Excellence Grant from the Czech Grant Agency and three more "GACR" grants - our success rate with GACR - over 8 years now - still remains at 100%!

Pasha may afterall get married to Asha :o) Vanda gave birth to her 3rd child in 5 years - amazing! Who is next? Perhaps I don't wanna know.... :) X-mas is behind the door! Oh my ... time really flies!

EMBO Workshop: Viral RNA: Structure, Function and Targeting - EMBL Heidelberg, March 5 - 7, 2007 EMBO Workshop: Viral RNA: Structure, Function and Targeting - EMBL Heidelberg, March 5 - 7, 2007