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Seminář Hanna-Mari Baldauf
Seminář Hanna-Mari Baldauf
“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV, which is a long standing interest in the lab. We use virological, cellular, biochemical, and evolutionary approaches to decipher motifs/pathways that…
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Seminář Lorena Arranz
Seminář Lorena Arranz
“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche.…
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Seminář Susana Minguet
Seminář Susana Minguet
“Harnessing TCR Discoveries for the Next Generation of Immunotherapies” Recent advances in synthetic immunology and CAR T cell engineering have highlighted the critical importance of signaling diversity for optimizing anti-tumor responses. Our work outlines the design of innovative cell-based cancer immunotherapies rooted in a molecular understanding of T cell activation via the T cell receptor…
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Seminář Lucie Janečková
Seminář Lucie Janečková
“NG2-lineage cell plasticity in ischemic brain repair: Roles of Wnt signaling” Focal cerebral ischemia (FCI) leads to neuronal loss followed by extensive tissue remodeling, in which glial and vascular cell populations play indispensable roles. Among these, NG2 glia and perivascular NG2⁺ cells represent highly plastic cell types that actively participate in post-ischemic responses, yet their functional…
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