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Seminář Anna Zitová
Seminář Anna Zitová
“Amphioxus point of view” Light, a crucial environmental signal, that drives lives of myriad creatures upon the Earth, regulating processes such as circadian rhythms, reproductive cycles, and visually guided behaviors. We all perceive light through specialized cells called photoreceptors. Behold Amphioxus, who possesses several distinct types of photoreceptors. It is also considered one of the…
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Seminář Lumír Krejčí
Seminář Lumír Krejčí
“Homologous Recombination – From repair of DSBs to processing stalled replication forks and human diseases” Homologous recombination (HR) is a central genome maintenance pathway that safeguards DNA integrity during both double-strand break (DSB) repair and replication stress. A key intermediate of HR is the nucleoprotein filament formed by RAD51 on single-stranded DNA, which mediates homology…
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Seminář Despoina Giamaki
Seminář Despoina Giamaki
“A hidden layer of chromatin regulation in neurological disease” Genome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response, regulated by PARP enzymes. Our research focuses on ARH3, an enzyme that removes mono-ADP-ribose from proteins, as its deficiency is linked to rare neurological disease.…
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Seminář Karolina Kowalska
Seminář Karolina Kowalska
“Mechanisms of MICAL regulation in actin filament disassembly” Actin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL, which selectively associates with and oxidizes actin filaments, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes…
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