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“Tipping the Lipid Scales: Negative Feedback Regulation via ORMDLs Protein Degradation Ensures Sphingolipid Homeostasis” Sphingolipids are essential lipid molecules that contribute to cellular structure and signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and catalyzed by the multimeric serine palmitoyltransferase (SPT) complex. The ER-resident ORMDL proteins are well-established regulators of sphingolipid…
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“RNA cap methylation in poxviruses and coronavirus – differences and similarities” RNA methyltransferases (MTases) are responsible for synthesizing the 5' RNA cap, which plays a crucial role in RNA stability and efficient translation. Over the past two years, both our research team and others have developed numerous inhibitors targeting coronaviral MTases. Through our efforts, we…
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“Birds do it their way: avian interferon regulatory factors (almost) resolved” Interferon regulatory factors (IRFs) are transcription factors that play a key role in vertebrate innate antiviral immunity. IRF3 and IRF7 activate the expression of IFN-β, which in response induces the assembly of STAT1, STAT2 and IRF9 into the ISGF3 complex. Subsequently, this complex activates…
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Dear colleagues, I am delighted to invite you to a seminar by Prof. Cheng Zhu (Georgia Institute of Technology, USA) at the Institute of Molecular Genetics on February 6 at 14:00 (Hasek Lecture Hall). Prof. Zhu is a recognized leader and pioneer at the interface of immunology, structural biology, and mechanosensing with groundbreaking contributions that…
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Seminář povedou Eva Oliva a Gabriela Langhammerová z NKC - gender a věda. Na semináři se dozvíte: - jaké jsou požadavky evropských i domácích grantových agentur - co je genderová dimenze a proč je důležité ji zohlednit - jaká je souvislost s ins􀀃tucionální změnou a plány genderové rovnos􀀃 - v čem spočívají koncepty intersekcionality a inkluzivity…
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“PIP2-RNA-protein interactions in phase separation of Pol II transcription” The RNA Polymerase II transcription is a multifaceted process crucial for gene expression in eukaryotic cells. Over the last decade, liquid-liquid phase separation (LLPS) was shown to be crucial in regulation of RNA pol II transcription. We have shown that nuclear phosphoinositides are pivotal for regulating biological…
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“Analysis of a novel chicken Pax6 mutant” Pax6 is known as the "master control gene" for eye formation, playing a crucial role in the development of the lens, retina, and other ocular structures. It drives the formation of the eye field, initiates lens differentiation, and helps establish the retina—all vital for vision. While the role of Pax6 in…
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“Transmembrane adaptor protein WBP1L: searching for its binding partners to understand its role in hematopoiesis” Transmembrane adaptor protein WBP1L, also known as Outcome Predictor of Acute Leukemia 1 (OPAL1) was identified nearly 20 years ago as a positive prognostic marker in childhood acute lymphoblastic leukemia. More recently, elevated WBP1L expression has also been linked to…
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“Fundamental principles during the egg-to-embryo transition” Fertilization initiates the egg-to-embryo transition, one of the most dramatic developmental transition resulting in the transformation of the egg from a dormant state into regulatorily and functionally distinct embryonic cells. While this transition has been studied extensively in respect to zygotic genome activation, the molecular mechanisms that mediate sperm-egg…
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“Reactivation of oncofetal genes reveals cellular heterogeneity and zonation in intestinal tumors” Colorectal cancer is one of the most common malignancies. Recent studies have shown that tumor cells can reactivate so-called oncofetal genes — genes normally expressed during embryonic development but silenced in healthy adult intestinal tissue. These include Trop2 and Sca1, both of which…
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“Probing the functional heterogeneity and hierarchy in mammary gland fibroblasts” In this talk, I will focus on the heterogeneity and hierarchy of mouse mammary fibroblasts - the predominant cell type of mammary stroma. By single cell RNA sequencing, genetic lineage tracing and microscopy we show that fibroblast transcriptomic clusters represent spatially differentiated populations with specific…
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