The DNA single-strand break repair capacity of the mammalian oocytes and embryos 

Lecturer: Nataliia Dudko, MSc. / Department of Cell Nucleus Plasticity

Annotation: The number of de novo mutations in mammalian oocytes and preimplantation embryos is substantially lower than in somatic cells, but the reasons for this phenomenon are unknown. In our study we focus on minor DNA lesions repaired via BER, as they are a common source of de novo mutations. We found that the abundance of BER proteins may not be the most critical factor in granting high genomic stability, and other factors such as chromatin landscape should be considered.

The seminar will take place on 12. 9. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS.

We look forward to your participation.