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“RORγt⁺ Regulatory T Cells establish a memory footprint for the primary microbiota” A balanced immune system relies on regulatory T cells (Tregs) to prevent excessive immune responses. While thymus-derived Tregs are well known, a unique subset of microbiota-specific, peripherally induced RORγt⁺ Tregs has emerged as a critical regulator of intestinal immunity and crosstalk with microbial…
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Barbara Cannon and Jan Nedergaard, Stockholm University

“PML nucleolar association: What is it and what does it do?” Promyelocytic leukemia protein (PML) is a multivalent stress response protein that, upon specific genotoxic stress, can organize into a unique structure that encloses nucleolar material, termed the PML-nucleolar association (PNA). PNAs were described in both senescent cells and cells harboring DNA damage. We investigated…
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"Cesta do nitra buňky" Během přednášky podnikneme cestu do nitra živé buňky. Ukážeme si, jaké nástroje vědci používají, aby odhalili její mikroskopické struktury, a jak lze tyto detaily převést do podoby, kterou můžeme spatřit pouhým okem. Zároveň zjistíme něco překvapivého – naše buňky mají víc společného, než byste čekali, s buňkami nebezpečných parazitů, například s…
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“Chromatin Architecture and Gene Regulation by Actin and Myosin in Health and Disease” Chromosomes are arranged in distinct chromosome territories, within which chromatin is further organized into chromatin compartments and topologically associating domains (TADs). By orchestrating DNA loops and promoter-enhancer interactions, this spatial organization of the genome plays a crucial role in gene expression and…
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Dear Colleagues,   We are pleased to announce the upcoming EMBO Practical Course "Super-resolution in Light Microscopy," taking place from June 15–22, 2025, Institute of Molecular Genetics of the Czech Academy of Sciences (IMG) in Prague.   This 8-day course combines theoretical talks, lectures from leading experts in the field, and practical demonstrations with hands-on…
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Lecture „The role of ryanodine receptors in muscle function“ Ryanodine receptors (RyR) are the Ca2+ release channel of skeletal muscle, which are responsible for rapidly releasing a large amount of Ca2+ upon electrical stimulation to evoke contraction. In the resting muscle, RyR leak Ca2+ and require the expenditure of energy to maintain steady state Ca2+…
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Prof. Bradley Launikonis, The University of Queensland, Brisbane, Australia