Akce

“Preclinical development of IL-15-based immunocytokine SOT201 and antibody-drug conjugate SOT106 for treatment of solid tumors” SOT201 is a novel cis-acting immunocytokine consisting of an antibody against PD-1 genetically fused to a sushi+ domain of IL-15Ra and IL-15 mutein. SOT201 targets PD-1+ TILs with a balanced cytokine potency to revive exhausted T cells in tumor microenvironment.…
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Dear friends and colleagues, it is my pleasure to invite you to a special seminar given by                       Prof. Sophie Janssens, PhD. VIB-UGent Center for Inflammation Research, Belgium Title: The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation   Monday, April 28, 2025 at 10 am, in Hasek's lecture hall, Institute…
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"SHOULD CANCER PATIENTS EAT DIFFERENTLY? Metabolomics-guided dietary intervention for optimal clinical use of anti-cancer MCL1 inhibitors.” Diet is the major source of nutrients for tumors. However, dietary interventions in cancer patients lack personalization. One of our active research areas is aimed at tailoring metabolomics-guided strategies to enhance the therapeutic effects of anti-cancer agents and/or ameliorate…
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“Structural and functional remodeling of the bone marrow stromal microenv. during tissue regeneration and acute myeloid leukemia” Bone marrow (BM) tissues are the prime sites for hematopoietic cell production, long-term reservoirs for immunological memory and hubs in which bone metabolism is orchestrated. The BM is comprised of a complex hematopoietic compartment, as well as a…
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Dear Colleagues, We are pleased to invite you to the 4th 10x Genomics Experience Meeting, taking place on May 12, 2025, from 10:00 AM to 4:00 PM at IMG (Hašek's Auditorium). Please find the detailed workshop program attached and join us for discussions on the current advancements in single-cell and spatial technologies. To ensure your…
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Dear all! If you wish to analyze your microscopy image data efficiently using techniques of artificial intelligence, YOU ARE INVITED to the practical course: AI-BASED SEGMENTATION AND TRACKING This intensive 2-day course takes place on May 13-14, 2025, at the Institute of Molecular Genetics of the Czech Academy of Sciences and focuses intensively on image…
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“Evolutionary diversification of actomyosin-driven early embryo morphogenesis” The shape of an animal arises during embryo morphogenesis and involves rotatory movements of cells relative to eachother. These movements are driven by forces that arise in the actomyosin cytoskeleton. Biophysical studies in C. elegans have unraveled many of the physcial mechanisms underlying morphogenetic cell rotations. However, little…
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“RORγt⁺ Regulatory T Cells establish a memory footprint for the primary microbiota” A balanced immune system relies on regulatory T cells (Tregs) to prevent excessive immune responses. While thymus-derived Tregs are well known, a unique subset of microbiota-specific, peripherally induced RORγt⁺ Tregs has emerged as a critical regulator of intestinal immunity and crosstalk with microbial…
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Barbara Cannon and Jan Nedergaard, Stockholm University

“PML nucleolar association: What is it and what does it do?” Promyelocytic leukemia protein (PML) is a multivalent stress response protein that, upon specific genotoxic stress, can organize into a unique structure that encloses nucleolar material, termed the PML-nucleolar association (PNA). PNAs were described in both senescent cells and cells harboring DNA damage. We investigated…
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"Cesta do nitra buňky" Během přednášky podnikneme cestu do nitra živé buňky. Ukážeme si, jaké nástroje vědci používají, aby odhalili její mikroskopické struktury, a jak lze tyto detaily převést do podoby, kterou můžeme spatřit pouhým okem. Zároveň zjistíme něco překvapivého – naše buňky mají víc společného, než byste čekali, s buňkami nebezpečných parazitů, například s…
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“Chromatin Architecture and Gene Regulation by Actin and Myosin in Health and Disease” Chromosomes are arranged in distinct chromosome territories, within which chromatin is further organized into chromatin compartments and topologically associating domains (TADs). By orchestrating DNA loops and promoter-enhancer interactions, this spatial organization of the genome plays a crucial role in gene expression and…
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