Akce

Dear colleagues, I would like to invite you to register online for the seminar course Advances in Molecular Biology and Genetics and share news concerning the course. The program of the 49th course is available here: https://pokroky.img.cas.cz/programme/ The course is a two week lecture series and is particularly suitable for individual study plans (ISPs) of the…
Více

“Role of B cells in central T cell tolerance” Tolerance to self-antigens is a fundamental property of the immune system. During central tolerance induction in the thymus, autoreactive T cells are either eliminated or diverted into the regulatory T cell lineage. Both processes are dependent on the presentation of self-antigens by thymic antigen presenting cells…
Více

“The atlas of placodal development helps to decipher their evolutionary origin” In this talk I will present our single cell and spatial transcriptomics data, which I will place into the light of the current ideas about the placodal evolution. Neurogenic placodes are specialized embryonic ectodermal thickenings in the head that give rise to sensory neurons,…
Více

Dear Colleagues, We are excited to invite you to an intensive introductory three-day course on Single-cell analysis - from qPCR to sequencing, organised by the Institute of Biotechnology (Radek Šindelka) and the Institute of Molecular Genetics (Michal Kolář). Dates: November 18, 19, and 21 Time: 9:00 AM – 3:00 PM Location: Krč Campus (IMG Lecture…
Více

Dear colleagues, on November 18th 2025 we will organize FlowJo™ 11 training with Ioannis Panetas, Ph.D.- application specialist from BD. FlowJo is a powerful cytometry data analysis software available to users of our Flow Cytometry Core Facility. More information about FlowJo: https://www.flowjo.com/solutions/flowjo This year, the training will focus on the new version 11, which, in…
Více

“Understanding the enteric nervous system development through the avian embryo model: implications for regenerative biology” In this presentation, I will provide an overview of enteric nervous system (ENS) development from the perspective of the avian embryo. The ENS, often referred to as the “second brain,” originates from vagal neural crest cells that migrate into the…
Více

“The immunoregulatory properties of the metabolite itaconate” In this talk I will present my latest findings of the function of immunoregulatory metabolite itaconate. Itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular mechanism of…
Více

Single-cell RNA sequencing (scRNA-seq) allows researchers to study gene expression at the level of individual cells. This approach can, for example, help to identify different cell populations in a complex sample and describe their expression patterns. To generate and analyse scRNA-seq data, several methods are available, all with their strengths and weaknesses depending on the…
Více

Doc. Ing. Tomáš Čajka Ph.D., Fyziologický ústav AV ČR, bude zajišťovat  21 th Metodologický seminář Krč – Biocev na téma: „Metabolomics and lipidomics: platforms, pitfalls, and practical tips“, který se bude konat 1.12.2025 od 15,00 hodin v Kinosále FGÚ. Anotace: Metabolomics and lipidomics are rapidly advancing fields that have transformed our understanding of biological processes at…
Více

“Nuclear myosin 1 – from gene to function” Mitochondria play a vital role in cellular metabolism by generating energy through oxidative phosphorylation (OXPHOS) in most somatic cells. However, highly proliferative, undifferentiated pluripotent stem cells and cancer cells mainly rely on aerobic glycolysis for energy production. Recently, we reported that nuclear myosin 1 (NM1) functions as…
Více

“Enigmatic germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes” Centromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore explain the unusual mitotic and meiotic behaviour of certain chromosomes, such as the germline-restricted chromosome (GRC) of songbirds. This chromosome is eliminated from somatic cells…
Více

“ALDH1A1 inhibition as a therapeutic target in Acute Myeloid Leukemia” Acute Myeloid Leukemia (AML) is a hematological malignancy leading to differentiation arrest of the myeloid compartment in the bone marrow. It is reported that high levels of ALDH1A1 inhibition promote chemoresistance in AML. Therefore, in my project we are studying the role of ALDH1A1 inhibition…
Více