Akce

“Initiating Mechanisms of Autoinflammatory Osteomyelitis: dysregulated neutrophil recruitment and tyrosine kinase signaling” Autoinflammatory diseases result from inappropriate activation of the innate immune system in the absence of infection. Loss of PSTPIP2, a membrane adaptor protein, leads to the development of one such disease Chronic Multifocal Osteomyelitis (CMO), an autoinflammatory disease in mice which serves as…
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“Characterization and targeted rescue of a novel PRPF31 mutation in retinitis pigmentosa” Retinitis pigmentosa (RP) is an inherited retinal disease characterized by photoreceptor loss. Mutations in the PRPF31 gene cause approximately 10% of cases of autosomal dominant RP. In this project, we characterize a novel intronic pathogenic variant in the PRPF31 gene. We provide evidence…
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Dear colleagues, We would like to invite you to join Lunch & Learn seminar focused on Panel Design Strategy in Flow Cytometry. This session is designed to support anyone involved in planning, optimizing, or performing multicolor flow cytometry experiments by providing both conceptual guidance and practical demonstrations.   More information and registration. Flyer   Registration…
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“Towards understanding life cycle of Trypanosoma brucei” Trypanosoma brucei is a unicellular eukaryotic parasite of mammals causing sleeping sickness in humans. T. brucei is transmitted by the tsetse fly. In the fly trypanosomes migrate from the gut to salivary glands, which is associated with a defined sequence of changes to cells of the parasite. We…
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“The Fall of the Helicase of Dicer” Dicer is an RNase III endoribonuclease that processes pre-miRNAs and dsRNAs into small RNAs of ~21–28 nt, serving the miRNA and RNAi pathways. In mammals, Dicer’s ability to process long dsRNA is constrained by its helicase domain. Consequently, the miRNA pathway predominates, and RNAi is considered vestigial. This…
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“Plectin Loss Disrupts Mechanotransduction and Attenuates Hepatic Stellate Cell Activation” Liver fibrosis, a hallmark of fibroproliferative disorders that contribute to nearly 45% of global mortality, is primarily driven by the activation of hepatic stellate cells (HSCs). In response to injury-induced tissue stiffening, HSCs undergo mechanosignaling-dependent activation and deposit excessive extracellular matrix (ECM), perpetuating a self-sustaining…
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“Mechanic and energetic principles of leukocyte locomotion” During metazoan development, immune surveillance and cancer dissemination, cells migrate in complex three-dimensional (3D) microenvironments. These are crowded by cells and extracellular matrix, generating mazes of differently sized spaces typically smaller than the diameter of the migrating cell. Most mesenchymal and epithelial cells actively generate their migratory path…
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“Amphioxus point of view” Light, a crucial environmental signal, that drives lives of myriad creatures upon the Earth, regulating processes such as circadian rhythms, reproductive cycles, and visually guided behaviors. We all perceive light through specialized cells called photoreceptors. Behold Amphioxus, who possesses several distinct types of photoreceptors. It is also considered one of the…
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“Homologous Recombination – From repair of DSBs to processing stalled replication forks and human diseases” Homologous recombination (HR) is a central genome maintenance pathway that safeguards DNA integrity during both double-strand break (DSB) repair and replication stress. A key intermediate of HR is the nucleoprotein filament formed by RAD51 on single-stranded DNA, which mediates homology…
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“A hidden layer of chromatin regulation in neurological disease” Genome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response, regulated by PARP enzymes. Our research focuses on ARH3, an enzyme that removes mono-ADP-ribose from proteins, as its deficiency is linked to rare neurological disease.…
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“Mechanisms of MICAL regulation in actin filament disassembly” Actin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL, which selectively associates with and oxidizes actin filaments, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes…
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