Akce

“Understanding the enteric nervous system development through the avian embryo model: implications for regenerative biology” In this presentation, I will provide an overview of enteric nervous system (ENS) development from the perspective of the avian embryo. The ENS, often referred to as the “second brain,” originates from vagal neural crest cells that migrate into the…
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“The immunoregulatory properties of the metabolite itaconate” In this talk I will present my latest findings of the function of immunoregulatory metabolite itaconate. Itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular mechanism of…
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Single-cell RNA sequencing (scRNA-seq) allows researchers to study gene expression at the level of individual cells. This approach can, for example, help to identify different cell populations in a complex sample and describe their expression patterns. To generate and analyse scRNA-seq data, several methods are available, all with their strengths and weaknesses depending on the…
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Doc. Ing. Tomáš Čajka Ph.D., Fyziologický ústav AV ČR, bude zajišťovat  21 th Metodologický seminář Krč – Biocev na téma: „Metabolomics and lipidomics: platforms, pitfalls, and practical tips“, který se bude konat 1.12.2025 od 15,00 hodin v Kinosále FGÚ. Anotace: Metabolomics and lipidomics are rapidly advancing fields that have transformed our understanding of biological processes at…
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“Nuclear myosin 1 – from gene to function” Mitochondria play a vital role in cellular metabolism by generating energy through oxidative phosphorylation (OXPHOS) in most somatic cells. However, highly proliferative, undifferentiated pluripotent stem cells and cancer cells mainly rely on aerobic glycolysis for energy production. Recently, we reported that nuclear myosin 1 (NM1) functions as…
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“Enigmatic germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes” Centromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore explain the unusual mitotic and meiotic behaviour of certain chromosomes, such as the germline-restricted chromosome (GRC) of songbirds. This chromosome is eliminated from somatic cells…
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“ALDH1A1 inhibition as a therapeutic target in Acute Myeloid Leukemia” Acute Myeloid Leukemia (AML) is a hematological malignancy leading to differentiation arrest of the myeloid compartment in the bone marrow. It is reported that high levels of ALDH1A1 inhibition promote chemoresistance in AML. Therefore, in my project we are studying the role of ALDH1A1 inhibition…
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“CD8+ T cells in infection: Orchestration of the effector and memory fates” In infection, naive CD8+ T cells differentiate into short-lived effector cells, which provide immediate protection against the pathogen, and long-lived memory cells, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families, we show…
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“Multiple Layers of Control in Early Sphingolipid Biosynthesis” Sphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity,…
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“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” Viruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs), many of which appear intact and may represent functional viruses. Some EVEs are…
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“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV, which is a long standing interest in the lab. We use virological, cellular, biochemical, and evolutionary approaches to decipher motifs/pathways that…
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“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche.…
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