“RORγt⁺ Regulatory T Cells establish a memory footprint for the primary microbiota”

A balanced immune system relies on regulatory T cells (Tregs) to prevent excessive immune responses. While thymus-derived Tregs are well known, a unique subset of microbiota-specific, peripherally induced RORγt⁺ Tregs has emerged as a critical regulator of intestinal immunity and crosstalk with microbial communities. Our data suggests that RORγt⁺ Tregs function as an immunological “memory,” safeguarding beneficial primordial microbiota, thus offering a novel paradigm for gut immune homeostasis.