Akce

“Multiple Layers of Control in Early Sphingolipid Biosynthesis” Sphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity,…
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“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” Viruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs), many of which appear intact and may represent functional viruses. Some EVEs are…
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“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV, which is a long standing interest in the lab. We use virological, cellular, biochemical, and evolutionary approaches to decipher motifs/pathways that…
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“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche.…
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“Harnessing TCR Discoveries for the Next Generation of Immunotherapies” Recent advances in synthetic immunology and CAR T cell engineering have highlighted the critical importance of signaling diversity for optimizing anti-tumor responses. Our work outlines the design of innovative cell-based cancer immunotherapies rooted in a molecular understanding of T cell activation via the T cell receptor…
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“NG2-lineage cell plasticity in ischemic brain repair: Roles of Wnt signaling” Focal cerebral ischemia (FCI) leads to neuronal loss followed by extensive tissue remodeling, in which glial and vascular cell populations play indispensable roles. Among these, NG2 glia and perivascular NG2⁺ cells represent highly plastic cell types that actively participate in post-ischemic responses, yet their functional…
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“Initiating Mechanisms of Autoinflammatory Osteomyelitis: dysregulated neutrophil recruitment and tyrosine kinase signaling” Autoinflammatory diseases result from inappropriate activation of the innate immune system in the absence of infection. Loss of PSTPIP2, a membrane adaptor protein, leads to the development of one such disease Chronic Multifocal Osteomyelitis (CMO), an autoinflammatory disease in mice which serves as…
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“Characterization and targeted rescue of a novel PRPF31 mutation in retinitis pigmentosa” Retinitis pigmentosa (RP) is an inherited retinal disease characterized by photoreceptor loss. Mutations in the PRPF31 gene cause approximately 10% of cases of autosomal dominant RP. In this project, we characterize a novel intronic pathogenic variant in the PRPF31 gene. We provide evidence…
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Dear colleagues, We would like to invite you to join Lunch & Learn seminar focused on Panel Design Strategy in Flow Cytometry. This session is designed to support anyone involved in planning, optimizing, or performing multicolor flow cytometry experiments by providing both conceptual guidance and practical demonstrations.   More information and registration. Flyer   Registration…
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“Towards understanding life cycle of Trypanosoma brucei” Trypanosoma brucei is a unicellular eukaryotic parasite of mammals causing sleeping sickness in humans. T. brucei is transmitted by the tsetse fly. In the fly trypanosomes migrate from the gut to salivary glands, which is associated with a defined sequence of changes to cells of the parasite. We…
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“The Fall of the Helicase of Dicer” Dicer is an RNase III endoribonuclease that processes pre-miRNAs and dsRNAs into small RNAs of ~21–28 nt, serving the miRNA and RNAi pathways. In mammals, Dicer’s ability to process long dsRNA is constrained by its helicase domain. Consequently, the miRNA pathway predominates, and RNAi is considered vestigial. This…
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“Plectin Loss Disrupts Mechanotransduction and Attenuates Hepatic Stellate Cell Activation” Liver fibrosis, a hallmark of fibroproliferative disorders that contribute to nearly 45% of global mortality, is primarily driven by the activation of hepatic stellate cells (HSCs). In response to injury-induced tissue stiffening, HSCs undergo mechanosignaling-dependent activation and deposit excessive extracellular matrix (ECM), perpetuating a self-sustaining…
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