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“Initiating Mechanisms of Autoinflammatory Osteomyelitis: dysregulated neutrophil recruitment and tyrosine kinase signaling” Autoinflammatory diseases result from inappropriate activation of the innate immune system in the absence of infection. Loss of…
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“Characterization and targeted rescue of a novel PRPF31 mutation in retinitis pigmentosa” Retinitis pigmentosa (RP) is an inherited retinal disease characterized by photoreceptor loss. Mutations in the PRPF31 gene cause…
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Dear colleagues, We would like to invite you to join Lunch & Learn seminar focused on Panel Design Strategy in Flow Cytometry. This session is designed to support anyone involved…
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“Towards understanding life cycle of Trypanosoma brucei” Trypanosoma brucei is a unicellular eukaryotic parasite of mammals causing sleeping sickness in humans. T. brucei is transmitted by the tsetse fly. In…
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“The Fall of the Helicase of Dicer” Dicer is an RNase III endoribonuclease that processes pre-miRNAs and dsRNAs into small RNAs of ~21–28 nt, serving the miRNA and RNAi pathways.…
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“Plectin Loss Disrupts Mechanotransduction and Attenuates Hepatic Stellate Cell Activation” Liver fibrosis, a hallmark of fibroproliferative disorders that contribute to nearly 45% of global mortality, is primarily driven by the…
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“Mechanic and energetic principles of leukocyte locomotion” During metazoan development, immune surveillance and cancer dissemination, cells migrate in complex three-dimensional (3D) microenvironments. These are crowded by cells and extracellular matrix,…
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“Amphioxus point of view” Light, a crucial environmental signal, that drives lives of myriad creatures upon the Earth, regulating processes such as circadian rhythms, reproductive cycles, and visually guided behaviors.…
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“Homologous Recombination – From repair of DSBs to processing stalled replication forks and human diseases” Homologous recombination (HR) is a central genome maintenance pathway that safeguards DNA integrity during both…
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“A hidden layer of chromatin regulation in neurological disease” Genome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response,…
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“Mechanisms of MICAL regulation in actin filament disassembly” Actin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal…
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