Akce

Trace Element and Speciation Analysis in Biological and Environmental Samples

The human eye is our primary tool for interpreting images, so scientific images should be adjusted with this perception in mind. However, display and print transfer characteristics often degrade images, making them differ from reality. This course offers a unique approach, focusing on preparing image data for presentation. We’ll cover essential topics like gamma correction…
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“Quality control in snRNP biogenesis” Before being assembled into spliceosomes, small nuclear ribonucleoprotein particles (snRNPs) undergo a complex and regulated maturation pathway. Cajal bodies (CBs) have been shown to monitor the final stage of this process by sequestering immature or misassembled particles through a yet unknown quality control mechanism. Here, we have identified coilin, a…
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Lukáš Chmátal, Ph.D., Whitehead Institute for Biomedical Research, MIT, USA Heart disease is the leading cause of death worldwide, but its effects are far from uniform. Men and women experience striking differences in symptoms, prevalence, and outcomes – yet the molecular mechanisms underlying these differences remain poorly understood. In this lecture, I will reveal how…
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“Structural basis of MICAL autoinhibition and activation” In this talk, we will explore the role of MICAL proteins in cellular dynamics, focusing on their ability to disassemble actin filaments and their implications for processes like axon guidance, cytokinesis, and cell morphology. We will present our recent findings based on the cryoEM structure of human MICAL1,…
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Modeling human early pregnancy with stem cells” The blastocyst is the early mammalian organism before implantation in the uterus. We have promoted the self-organization of stem cells into models of mouse and human blastocysts, which we have named blastoids (Nature 2018, Nature 2021). Blastoids are morphologically and transcriptionally similar to the blastocyst and contain analogs…
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“Infections and hematopoietic stem cells: how do they communicate?” Infections are primarily cleared by immune cells in our bodies. However, we observed that the most immature hematopoietic stem cells also contribute to this process. In this lecture, we will report on the mechanisms that activate an hematopoietic stem cell during infection and the cellular adaptations that…
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Speaker: Martina Rauner, Technische Universität Dresden, Germany

“Tipping the Lipid Scales: Negative Feedback Regulation via ORMDLs Protein Degradation Ensures Sphingolipid Homeostasis” Sphingolipids are essential lipid molecules that contribute to cellular structure and signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and catalyzed by the multimeric serine palmitoyltransferase (SPT) complex. The ER-resident ORMDL proteins are well-established regulators of sphingolipid…
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“RNA cap methylation in poxviruses and coronavirus – differences and similarities” RNA methyltransferases (MTases) are responsible for synthesizing the 5' RNA cap, which plays a crucial role in RNA stability and efficient translation. Over the past two years, both our research team and others have developed numerous inhibitors targeting coronaviral MTases. Through our efforts, we…
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“Birds do it their way: avian interferon regulatory factors (almost) resolved” Interferon regulatory factors (IRFs) are transcription factors that play a key role in vertebrate innate antiviral immunity. IRF3 and IRF7 activate the expression of IFN-β, which in response induces the assembly of STAT1, STAT2 and IRF9 into the ISGF3 complex. Subsequently, this complex activates…
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Dear colleagues, I am delighted to invite you to a seminar by Prof. Cheng Zhu (Georgia Institute of Technology, USA) at the Institute of Molecular Genetics on February 6 at 14:00 (Hasek Lecture Hall). Prof. Zhu is a recognized leader and pioneer at the interface of immunology, structural biology, and mechanosensing with groundbreaking contributions that…
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