Akce

“Transmembrane adaptor protein OPAL1 regulates leukocyte hematopoiesis and thymus development” Expression of transmembrane adaptor protein Outcome predictor of acute leukemia 1 (OPAL1), has been linked to the ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. Our research also suggests that it has an important role in leukocyte development. We show that in mice with germline…
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"Targeting plectin-mediated cytoskeletal crosstalk in hepatocellular carcinoma" Anotace: The study's findings indicate that the elevation of plectin in tumor hepatocytes is associated with the progression of hepatocellular carcinoma (HCC). This progression can be inhibited through genetic or pharmacological targeting of plectin. The oncogenic and invasive potentials of HCC cells are attenuated through plectin ablation, suggesting…
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Ing. Michal Pravenec, DrSc., Laboratory of Genetics of Model Diseases, IPHYS

μLectures is a new monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session, lasting 30 minutes, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments, giving them a better overview of the options available…
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“Janus Kinase 2 (JAK2) mutations: implications for blood diseases” The project aims to elucidate the impact of the germline Jak2 R1063H variant on myeloproliferative disorders and its potential implication in myeloid malignancy predisposition. Utilizing a mouse model harboring the Jak2 R1063H mutation, we observed higher mortality rate, elevated D-dimer levels indicative of thrombotic events, and…
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“Single-cell to tissue-scale memory of infection and inflammation” The role of epithelial and stromal cells in driving inflammation, together with immune cells, is being increasingly appreciated. However, we currently lack tissue-scale frameworks to define and test how inflammation collectively impacts epithelial, stromal, and immune cells. This poses a fundamental challenge for understanding the cellular mechanisms that drive…
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Maternal diet quality and health status of newborns Lecturer: Mgr. Jitka Pavlíková, Ph.D. / Department of Toxicology a Molecular Epidemiology Annotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time, become part of food chains, and some of them accumulate in living organisms. These substances are being monitored for…
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RNDr. Katarína Smolková, Ph.D., Laboratory of Mitochondrial Physiology, IPHYS  

“The impact of genetic cheating on mammalian reproduction and speciation”  Selfish DNA violate Mendel’s Law of Segregation by biased segregation to the egg cell. This genetic cheating, meiotic drive, is a widespread phenomenon across eukaryotes with associated fitness costs such as fertility issues. I will discuss our recent work on the cell biological mechanism of…
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Prof. Sven Enerbäck, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Sweden.

“Chromatin ADP-ribosylation in neurodegenerative disease” ADP-ribosylation is a common protein post-translational modification that regulates numerous cellular processes, including transcription, cell proliferation and differentiation, immune and stress responses, aging, and cell death. One of its most extensively studied roles is in DNA damage response and subsequent DNA repair. Moreover, deregulation of ADP-ribose metabolism is linked to…
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Prof. John D. Imig, University of Arkansas for Medical Sciences, USA