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μLectures is a new, monthly seminar series designed to enhance researchers’ understanding of the fundamental workings and principles of microscopy. Each session, lasting 30 minutes, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments, giving them better overview of the options available…
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“Splicing in the world of marine diplonemids” Recent surveys of marine biodiversity have revealed the abundance and diversity of planktonic diplonemids. By sequencing the genomes and transcriptomes of six marine diplonemids and performing comprehensive splice site analyses, we identified numerous non-canonical introns and mapped their common features, shedding light on the evolution of RNA splicing…
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Dr. Ingo Greger, Neurobiology Division MRC Laboratory of Molecular Biology, Cambridge, UK

“Role of pax6 genes in the eye during embryonal development of medaka” Pax6 is remarkably conserved across a wide range of species, from flies to humans, signifying its fundamental role in the regulatory network governing eye formation. In this presentation, we will delve into the functions of three pax6 genes – Pax6.1, Pax6.2, and Pax6.3…
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Subpopulations of NG2 glia in the adult mouse brain after focal cerebral ischemia. Lecturer: Mgr. Tomáš Knotek / Department of Cellular Neurophysiology Annotation: Glia expressing NG2 antigen are known predominantly as precursors of oligodendrocytes. However, their differentiation potential in tissue affected by ischemic injury has not yet been fully explored. To further our understanding of these cells, we…
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“Transmembrane adaptor protein OPAL1 regulates leukocyte hematopoiesis and thymus development” Expression of transmembrane adaptor protein Outcome predictor of acute leukemia 1 (OPAL1), has been linked to the ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. Our research also suggests that it has an important role in leukocyte development. We show that in mice with germline…
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"Targeting plectin-mediated cytoskeletal crosstalk in hepatocellular carcinoma" Anotace: The study's findings indicate that the elevation of plectin in tumor hepatocytes is associated with the progression of hepatocellular carcinoma (HCC). This progression can be inhibited through genetic or pharmacological targeting of plectin. The oncogenic and invasive potentials of HCC cells are attenuated through plectin ablation, suggesting…
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Ing. Michal Pravenec, DrSc., Laboratory of Genetics of Model Diseases, IPHYS

μLectures is a new monthly seminar series designed to enhance researchers’ understanding of microscopy’s fundamental workings and principles. Each session, lasting 30 minutes, will focus on a specific concept or topic within microscopy. The practical information presented aims to deepen researchers’ comprehension of their microscopy experiments, giving them a better overview of the options available…
Více

“Janus Kinase 2 (JAK2) mutations: implications for blood diseases” The project aims to elucidate the impact of the germline Jak2 R1063H variant on myeloproliferative disorders and its potential implication in myeloid malignancy predisposition. Utilizing a mouse model harboring the Jak2 R1063H mutation, we observed higher mortality rate, elevated D-dimer levels indicative of thrombotic events, and…
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“Single-cell to tissue-scale memory of infection and inflammation” The role of epithelial and stromal cells in driving inflammation, together with immune cells, is being increasingly appreciated. However, we currently lack tissue-scale frameworks to define and test how inflammation collectively impacts epithelial, stromal, and immune cells. This poses a fundamental challenge for understanding the cellular mechanisms that drive…
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Maternal diet quality and health status of newborns Lecturer: Mgr. Jitka Pavlíková, Ph.D. / Department of Toxicology a Molecular Epidemiology Annotation: Persistent organic pollutants are compounds of mostly anthropogenic origin that persist in the environment for a long time, become part of food chains, and some of them accumulate in living organisms. These substances are being monitored for…
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