22th of July, 2024
Kristina’s Tma manu has just been accepted in Communication Biology from the Nature Portfolio publishing group! 🤯🥳 Big congrats and many thanks for your practically independent work 👍👍! With this accomplishment, Kristina's path to her PhD degree is clear and leads in only one direction ... to nail it down soon 💪Fingers crossed! 🤙
15th of July, 2024
Guess what? Nawal, our new PhD student from Lebanon, has joined the lab (and brought us an excellent assortment of baklava and cones of mystical Cedrus libani with a very pleasant scent) and Leos was elected to the EMBO Membership. Most importantly, Terka is organizing a summer barbecue at the end of July before leaving us for her eagerly awaited maternity duties 😁
16th of June, 2024
We Are the Champions, my Friends! First of all, Peta, Nawal, Srinjoyee and Pragya have successfully passed their PhD admission exams! Hold on to your hats, ladies, the PhD roller coaster is about to get underway. The best of luck!
Then Dr. Zuzka and Dr. Terka super-successfully defended their PhD theses … biiiig congratulations, dear doctors, and a million thanks for your hard, wonderful work!!!
And finally, Adri and I finished our first lecture series with the exam of our first students. Our summer semester lecture is called: “Everything you wanted to know about gene expression but were afraid to ask.” The students reportedly enjoyed it a lot, so dear future students, do not hesitate to sign up for it in 2024/5 😊
Other than that, Zuzka’s NSMB is still … under second re-review … amazing how long it’s taking there…, and Kristina’s revised Comm Biol has just been submitted. Fingers crossed and everyone, hey, enjoy the summer! 🌞
5th of June, 2024
We are very pleased to announce that our new soon-to-be PhD student Pragya joined the lab yesterday morning. This morning, being lost in Prague’s public transport (sitting in a wrong tram), she texted this worrisome SMS to Filip ii. 😵💫 … well, only time will tell, if she really “took the wrong team” 😁. Hopefully not! We will definitely do our best to prove her wrong! 😎
Other than that, Terka and Zuzka will defend their PhD theses in exactly 10 days!🙈 And Peťa, Nawal, Srinjoyee and Pragya (if she stays with us till then 🙂) will be taking the PhD admission exam in 4 days! 🤯 Fingers crossed, ladies!!! 🤞🤞
2nd of May, 2024
This Monday and Tuesday, our lab hosted the COST-Translacore MC Meeting 2024. We heard cool talks from PIs and students from so-called Short-Term Scientific Missions, put on a science & art exhibition organized by Marek Tchorzewski (artists from all over the world were asked to express the mission of Translacore in various graphics – see three examples below, more here: https://translacore.eu/), guided the participants through the Kunraticky Forest to the Hunter’s restaurant to enjoy Svickovou na smetane s knedlikem, etc. We hope all participants had fun 😊 C U next year in Montenegro 😎🙌
Btw, we have unofficially learned that our lab has unofficially won the GAČR (Czech Science Foundation) President’s Award 2023 for the best research project in the field of Medical and Biological Sciences. However, since we won it also in 2020 and according to the rules, it cannot be awarded twice to the same lab, the award will go to the next in line and not to us.🤯 Nevertheless, an official letter was sent to us congratulating us on our great achievements, which is very nice and we appreciate it very much.🤙 And last but not least, “summer” is in full force again!🌞
We are a medium-sized group (~15 people) of enthusiastic, passionate and hard-working “musicians” from post-docs to undergraduate students with one skillful lab assistant, who are eager to learn more and more every day while having fun at the same time. Our recording studio is based at the Institute of Microbiology (IMIC) of the Czech Academy of Sciences (CAS) in Prague, Czech Republic.
Our band nicknamed Laboratory of Regulation of Gene Expression (LRGE) was established in June 2006 and investigates fundamentals of one of the key, life-giving molecular processes in the cell and its regulation at both general as well as gene-specific levels. We R talking about protein synthesis! Simply speaking, our mostly basic research is focused on figuring out how the cell deciphers the genetic code of DNA using relatively simple decoding keys and uses this gene-encoded information to produce proteins, i.e., cellular effectors, through a very complex process also called translation.
Recently, we have become very much interested in various alternatives to these decoding keys, so-called alternative genetic codes, the detailed knowledge of which could be exploited in the treatment of various genetic diseases. In addition, we are interested in understanding how translation is regulated in response to constantly changing environmental conditions that the cell faces and to which it must immediately respond in order to adapt its repertoire of proteins that it is currently producing.
As for the importance of our research from the socio-economic and medical perspectives, we want to broaden and deepen the general understanding of how these basic cellular processes properly operate in the cell, so that our collaborators who are primarily interested in applied research; i.e., research directly aimed at developing the most appropriate treatment for a particular disease, can feed from it while investigating various pathologies.
Overall, paying the utmost tribute to our distinguished ancient predecessors, our major goal is to help to transmute lead ( basic research discoveries) into gold (useful therapeutics) with the simplest and finest tones.
Our compositions combine the use of mammalian cells lines and partly also the budding yeast Saccharomyces cerevisiae model organism and employ tools of molecular and structural biology, biochemistry and genetics.
We also very much enjoy participating in numerous popularization gigs (like Open Science, Researcher’s Night, etc.), giving interviews to news and radio, contributing to popularization magazines, etc.
Our band won “The best original research publication carried out at the Institute of Microbiology CAS Award” (our home institute) in years 2008, 2011, 2013, 2015, 2016, 2017, 2018, 2019, 2020, 2021, and 2022. In February 2016, the international evaluation committee selected our band as one of the 13 most prestigious ones in the entire CAS.
Our recording is (or until recently was) supported by the national and world renowned funding bodies such as the the Wellcome Trust, Howard Hughes Medical Institute, NIH FIC, German Science Foundation, Czech Science Foundation and Czech Academy of Sciences (Praemium Academiae). Altogether, we have produced >75 records with record labels like Nature (see our winning cover page), Molecular Cell, Nature Protocols, Nucleic Acids Research, Genes & Development, EMBO J., eLife, etc. Music is always composed by LRGE, lyrics usually by LSV.
Group leader
e-mail: valasekl@biomed.cas.cz
post-doctoral fellow
e-mail: herrmannova@biomed.cas.cz
post-doctoral fellow
e-mail: beznoskova@biomed.cas.cz
post-doctoral fellow
e-mail: mpasha@biomed.cas.cz
post-doctoral fellow
e-mail: jana.chumova@biomed.cas.cz
post-doctoral fellow
e-mail: jana.vojtova@biomed.cas.cz
post-doctoral fellow
e-mail:adriana.roithova@biomed.cas.cz
post-doctoral fellow
e-mail: vladislava.hronova@biomed.cas.cz
post-doctoral fellow
e-mail: filip.brazdovic@biomed.cas.cz
post-doctoral fellow
e-mail: filip.trcka@biomed.cas.cz
Ph.D. student
e-mail: zuzana.pavlikova@biomed.cas.cz
Ph.D. student
e-mail: terezie.svobodova@biomed.cas.cz
Ph.D. student
e-mail: anna.smirnova@biomed.cas.cz
Ph.D. student
e-mail: kristina.jendruchova@biomed.cas.cz
Ph.D. student
e-mail: klara.pospisilova@biomed.cas.cz
Ph.D. student
e-mail: adriana.subrtova@biomed.cas.cz
Master's student
e-mail: petra.miletinova@biomed.cas.cz
Ph.D. student
e-mail: to_be_announced@biomed.cas.cz
Ph.D. student
e-mail: to_be_announced@biomed.cas.cz
Ph.D. student
e-mail: to_be_announced@biomed.cas.cz
Lab assistant
e-mail: olga.krydova@biomed.cas.cz
Institute of Microbiology, AS CR, v.v.i.
Vídeňská 1083, Prague 4, 142 20
Czech Republic
Phone: +420 241 062 288 (2483)
Cell: +420 724 731 661
e-mail: valasekl@biomed.cas.cz
Take C-line metro to the station „Kačerov“.
Get on the bus 138 to the final station "Ústavy akademie věd".
We are in the Bldg. L, second floor, lab #128.
created by DALL·E 3
Guess the song:
Pa papa pa papapapa pa, pa papa pa papapapa pa, pa pa papapapapa pa, papapapapa pa... what is it? :o)
Guess the songs:
🔇🔈🔉🔊
👁️🐅
☀️🏖️ 6️⃣9️⃣
☔ 👨🌧️👨