SHORT COMMUNICATION

Reciprocal Adaptive Response of Human Peripheral Lymphocytes Induced by Bleomycine or Gamma Rays

I. Kalina, P. Brezáni, V. Habalová, A. Kohút1, E. Biroš, G. Némethová, J. Šalagovič

Department of Medical Biology and 1Department of Pharmacology, Medical Faculty, P.J. Šafárik University, Košice, Slovak Republic

Received July 10, 1998
Accepted January 26, 1999

Summary
The adaptive response and reciprocal adaptive response induced in vitro by exposure to low doses of gamma rays (0.05 Gy) or bleomycin (0.05 µ g/ml) in human peripheral blood lymphocytes were assessed by the frequency of chromosome aberrations. Gamma rays (1.5 Gy) or bleomycin (1.5 µ g/ml) were used as the challenge doses. In the experiments, blood samples from 5 healthy donors were investigated. It has been found that low doses of bleomycin and gamma rays induced a reciprocal adaptive response to high doses of gamma rays or bleomycin. Moreover, the results confirmed that the adaptive response did not correlate with the radiosensitivity of the peripheral blood lymphocytes.

Key words
Adaptive response · Reciprocal adaptive response · Gamma rays · Bleomycin · Chromosome aberration