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Seminář Veronika Niederlová
Seminář Veronika Niederlová
“CD8+ T cells in infection: Orchestration of the effector and memory fates” In infection, naive CD8+ T cells differentiate into short-lived effector cells, which provide immediate protection against the pathogen, and long-lived memory cells, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families, we show…
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Seminář Viktor Bugajev
Seminář Viktor Bugajev
“Multiple Layers of Control in Early Sphingolipid Biosynthesis” Sphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity,…
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