Structural Biology of Signaling Proteins - Institute of Physiology AS CR, v.v.i.

Kohoutova K, Dočekal V, Ausserlechner MJ, Kaiser N, Tekel A, Mandal R, Horvath M, Obsilova V, Vesely J, Hagenbuchner J and Obsil T

Lengthening the Guanidine-Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

ACS Omega. 7(38):34632-34646. 2022

IF = 4.132

Joshi R, Pohl P, Strachotova D, Herman P, Obsil T and Obsilova V

Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains

Biophys. J. 121(7):1299-1311. 2022

IF = 4.033

Mandal R, Kohoutova K, Petrvalska O, Horvath M, Srb P, Veverka V, Obsilova V and Obsil T

FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA

Protein Sci. 31:e4287. 2022

IF = 8

2021

Obsilova V, Honzejkova K and Obsil T

Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

Int. J. Mol. Sci. 22(24):13395. 2021

IF = 5.923

Horvath M, Petrvalska O, Herman P, Obsilova V and Obsil T

14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

Commun. Biol. 4(1):986. 2021

IF = 6.268

Pohl P, Joshi R, Petrvalska O, Obsil T and Obsilova V

14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

Commun. Biol. 4(1):899. 2021

IF = 6.268

Neves JF, Petrvalska O, Bosica F, Cantrelle FX, Merzougui H, O

Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer

FEBS J. 288(6):1918-1934. 2021

IF = 4.739

2020

Obsilova V and Obsil T

The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases

Int. J. Mol. Sci. 21(22):8824. 2020

IF = 4.556

Lentini Santo, D., Petrvalska O., Obsilova V., Ottmann C. and Obsil T.

Stabilization of protein-protein interactions between CaMKK2 and 14-3-3 by fusicoccins

ACS Chem Biol. 15(11):3060-3071. 2020

IF = 4.434

Obsilova V and Obsil T

A new role for 14-3-3 protein in steroidogenesis

FEBS J. 287(18):3921-3924. 2020

IF = 4.739

Kalabova D, Filandr F, Alblova M, Petrvalska O, Horvath M, Man P, Obsil T, Obsilova V

14-3-3 protein binding blocks the dimerization interface of caspase-2

FEBS J. 287(16):3494-3510. 2020

IF = 4.739

Psenakova K, Hexnerova R, Srb P, Obsilova V, Veverka V, Obsil T

The redox active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress.

FEBS J. 287(8):1626-1644. 2020

IF = 4.739

2019

Valenti D, Neves JF, Cantrelle FX, Hristeva S, Lentini Santo D, Obsil T, Hanoulle X, Levy LM, Tzalis D, Landrieu I, Ottmann C

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Medchemcomm. 10(10):1796-1802. 2019

IF = 2.807

Hagenbuchner J, Obsilova V, Kaserer T, Kaiser N, Rass B, Psenakova K, Docekal V, Alblova M, Kohoutova K, Schuster D, Aneichyk T, Vesely J, Obexer P, Obsil T, Ausserlechner MJ

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

Elife. 8. pii: e48876. 2019

IF = 7.551

Psenakova K, Kohoutova K, Obsilova V, Ausserlechner MJ, Veverka V, Obsil T.

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics.

Cells. 8(9). pii: E966. 2019

IF = 5.656

Smidova A, Stankova K, Petrvalska O, Lazar J, Sychrova H, Obsil T, Zimmermannova O, Obsilova V

The activity of Saccharomyces cerevisiae Na+, K+/H+ antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481

Biochim Biophys Acta Mol Cell Res. 1866(12):118534. 2019

IF = 4.739

Alblova M, Smidova A, Kalabova D, Lentini Santo D, Obsil T, Obsilova V

Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein

Physiol Res. 68(2):147-160. 2019

IF = 1.324

2018

Smidova A, Alblova M, Kalabova D, Psenakova K, Rosulek M, Herman P, Obsil T, Obsilova V

14-3-3 protein masks the nuclear localization sequence of caspase-2

FEBS J. 285(22):4196-4213. 2018

IF = 4.739

Kylarova S, Psenakova K, Herman P, Obsilova V, Obsil T

CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert

Biochim. Biophys. Acta-Gen. Subj. 1862(10):2304-2313. 2018

IF = 3.681

Psenakova K, Petrvalska O, Kylarova S, Lentini Santo D, Kalabova D, Herman P, Obsilova V, Obsil T.

14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)

Biochim. Biophys. Acta-Gen. Subj. 1862(7):1612-1625. 2018

IF = 3.681

2017

Alblova M, Smidova A, Docekal V, Vesely J, Herman P, Obsilova V, Obsil T.

Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.

Proc Natl Acad Sci U S A. 114(46):E9811-E9820. 2017

IF = 9.504

Obsil T, Obsilova V.

Structural aspects of protein kinase ASK1 regulation.

Adv Biol Regul. 66:31-36. 2017

IF = 0

Kalabova D, Smidova A, Petrvalska O, Alblova M, Kosek D, Man P, Obsil T, Obsilova V

Human procaspase-2 phosphorylation at both S139 and S164 is required for 14-3-3 binding.

Biochem Biophys Res Commun. 493(2):940-945. 2017

IF = 2.559

Kacirova M, Novacek J, Man P, Obsilova V, Obsil T.

Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function

Biophys J. 112(7):1339-1349. 2017

IF = 3.495

2016

Kylarova S, Kosek D, Petrvalska O, Psenakova K, Man P, Vecer J, Herman P, Obsilova V and Obsil T

Cysteine residues mediate high-affinity binding of thioredoxin to ASK1

FEBS J. 283(20):3821-3838. 2016

IF = 3.902

Petrvalska O, Kosek D, Kukacka Z, Tosner Z, Man P, Vecer J, Herman P, Obsilova V and Obsil T

Structural Insight into the 14-3-3 Protein-Dependent Inhibition of Protein Kinase ASK1

J Biol Chem. 291(39):20753-65. 2016

IF = 4.125

Jirku M, Lansky Z, Bednarova L, Sulc M, Monincova L, Majer P, Vyklicky L, Vondrasek J, Teisinger J, Bousova K.

The characterization of a novel S100A1 binding site in the N-terminus of TRPM1.

Int J Biochem Cell Biol. 78:186-193. 2016

IF = 3.505

Kirubakaran P, Pfeiferova L, Bousova K, Bednarova L, Obsilova V, Vondrasek J.

Artificial proteins as allosteric modulators of PDZ3 and SH3 in two-domain constructs: A computational characterization of novel chimeric proteins.

Proteins. 84(10):1358-74. 2016

IF = 2.289

2015

Jirku M, Bumba L, Bednarova L, Kubala M, Sulc M, Franek M, Vyklicky L, Vondrasek J, Teisinger J, Bousova K

Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel

Biophys Chem. 207:135-42. 2015

IF = 2.363

Bousova K, Jirku M, Bumba L, Bednarova L, Sulc M, Franek M, Vyklicky L, Vondrasek J, Teisinger J

PIP2 and PIP3 interact with N-terminus region of TRPM4 channel

Biophys Chem. 205:24-32. 2015

IF = 2.363

Kacirova M, Kosek D, Kadek A, Man P, Vecer J, Herman P, Obsilova V, Obsil T

Structural Characterization of Phosducin and its Complex with the 14-3-3 Protein

J Biol Chem 290(26):16246-60. 2015

IF = 4.258

Grycova L, Holendova B, Lansky Z, Bumba L, Jirku M, Bousova K, Teisinger J

Ca2+ Binding Protein S100A1 Competes with Calmodulin and PIP2 for Binding Site on the C-Terminus of the TPRV1 Receptor

ACS Chemical Neuroscience 6(3):386-92. 2015

IF = 4.348

2014

Kosek D, Kylarova S, PsenakovaK, Rezabkova L, Herman P, Vecer J, Obsilova V, Obsil T

Biophysical and Structural Characterization of the Thioredoxin-Binding Domain of Protein Kinase ASK1 and its Interaction with Reduced Thioredoxin

J Biol Chem 289(35):24463-24474. 2014

IF = 4.6

Kopecka M, Kosek D, Kukacka Z, Rezabkova L, Man P, Novak P, Obsil T, Obsilova V

Role of the EF-hand like motif in the 14-3-3 protein-mediated activation of yeast neutral trehalase Nth1

J Biol Chem 289(20):13948-13961. 2014

IF = 4.6

Obsilova V, Kopecka M, Kosek D, Kacirova M, Kylarova S, Rezabkova L, Obsil T.

Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation.

Physiol Res. 63 Suppl 1:S155-64. 2014

IF = 1.531

2013

Vacha P, Zuskova I, Bumba L, Herman P, Vecer J, Obsilova V, Obsil T.

Detailed kinetic analysis of the interaction between the FOXO4–DNA-binding domain and DNA.

Biophysical Chemistry 184:68-78. 2013

IF = 2.283

Macakova E, Kopecka M, Kukacka Z, Veisova D, Novak P, Man P, Obsil T, Obsilova V

Structural basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1

Biochimica Et Biophysica Acta-General Subjects 1830(10):4491-4499. 2013

IF = 3.848

Boukalova S, Teisinger J, Vlachova V.

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel

Biochimica Et Biophysica Acta-Molecular Cell Research 1833(3):520-8. 2013

IF = 4.808

Bily J, Grycova L, Holendova B, Jirku M, Janouskova H, Bousova K, Teisinger J.

Characterization of the S100A1 Protein Binding Site on TRPC6 C-Terminus

PLoS One. 8(5):e62677. 2013

IF = 3.73

2012

Rezabkova L, Kacirova M, Sulc M, Herman P, Vecer J, Stepanek M, Obsilova V, Obsil T

Structural modulation of phosducin by the phosphorylation and the 14-3-3 protein binding

Biophysical Journal 103(9):1960–1969. 2012

IF = 3.668

Grycova L, Holendova B, Bumba L, Bily J, Jirku M, Lansky Z, Teisinger J.

Integrative Binding Sites within Intracellular Termini of TRPV1 Receptor.

PLoS One. 7(10):e48437. 2012

IF = 3.73

Holendova B, Grycova L, Jirku M, Teisinger J.

PtdIns(4,5)P 2 interacts with CaM binding domains on TRPM3 N-terminus

Channels (Austin). 6(6). 2012

IF = 2.159

Krasny L, Pompach P, Strohalm M, Obsilova V, Strnadova M, Novak P and Volny M.

In-situ enrichment of phosphopeptides on MALDI plates modified by ambient ion landing.

J Mass Spectrom. 47(10):1294–1302. 2012

IF = 3.214

Haladova K, Mrazek H, Jecmen T, Halada P, Man P, Novak P, Chmelik J, Obsil T, Sulc M.

The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3ζ homodimer interface.

J Struct Biol. 179(1):10-7. 2012

IF = 3.361

Holakovska B, Grycova L, Jirku M, Sulc M, Bumba L, Teisinger J.

Calmodulin and S100A1 interact with N-terminus of TRPM3 channel.

J Biol Chem. 287(20):16645-55. 2012

IF = 4.651

Veisova D, Macakova E, Rezabkova L, Sulc M, Vacha P, Sychrova H, Obsil T, Obsilova V.

Role of individual phosphorylation sites for the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.

Biochem J. 443(3):663-70. 2012

IF = 4.654

2011

Rezabkova L, Man P, Novak P, Herman P, Vecer J, Obsilova V, Obsil T.

Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G-Protein signaling 3 (RGS3) function.

J Biol Chem. 286(50):43527-36. 2011

IF = 5.328

Obsil T, Obsilova V.

Structural basis of 14-3-3 protein functions.

Semin Cell Dev Biol. 22(7):663-72. 2011

IF = 6.342

Obsil T, Obsilova V.

Structural basis for DNA recognition by FOXO proteins.

Biochim Biophys Acta. 1813(11):1946-53. 2011

IF = 4.374

Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic SS.

Activation and regulation of purinergic P2X receptor channels.

Pharmacol Rev. 63(3):641-83. 2011

IF = 18.861

Valis K, Prochazka L, Boura E, Chladova J, Obsil T, Rohlena J, Truksa J, Dong LF, Ralph SJ, Neuzil J.

Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.

Cancer Res. 71(3):946-54. 2011

IF = 7.543

Touska F, Marsakova L, Teisinger J, Vlachova V.

A "Cute" Desensitization of TRPV1.

Curr Pharm Biotechnol. 12(1):122-9. Review. 2011

IF = 3.455

Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, Vlachova V.

The C-terminal basic residues contribute to the chemical and voltage-dependent activation of TRPA1.

Biochem J. 433(1):197-204. 2011

IF = 5.016

Holakovska B, Grycova L, Bily J, Teisinger J.

Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails.

Amino Acids 40(2):741-8. 2011

IF = 4.106

2010

Stojilkovic SS, Yan Z, Obsil T, Zemkova H.

Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.

Cell Mol Neurobiol. 30(8):1251-8, 2010.

IF = 3.226

Veisova, D., Rezabkova, L., Stepanek, M., Novotna, P., Herman, P., Vecer, J., Obsil, T., Obsilova, V.

C-terminal segment of yeast BMH proteins exhibits different structure compared to other 14-3-3 protein isoforms.

Biochemistry 49(18), 3853-3861, 2010

IF = 3.226

Rezabkova, L., Boura, E., Herman, P., Vecer, J., Bourova, L., Sulc, M., Svoboda, P., Obsilova, V., Obsil

14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G-protein signaling 3 (RGS3).

J. Struct. Biol. 170(3), 451-461, 2010

IF = 3.673

Boura E, Rezabkova L, Brynda J, Obsilova V, Obsil T.

Crystal structure of human FOXO4-DBD/DNA complex at 1.9 A resolution reveals new details on FOXO binding to the DNA

Acta Crystallogr D Biol Crystallogr. 66(Pt 12):1351-7, 2010.

IF = 14.103

Friedlova E, Grycova L, Holakovska B, Silhan J, Janouskova H, Sulc M, Obsilova V, Obsil T, Teisinger J.

The interactions of the C-terminal region of the TRPC6 channel with calmodulin.

Neurochem Int. 56(2):363-6, 2010.

IF = 3.541

Boukalova S, Marsakova L, Teisinger J, Vlachova V.

Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive TRPV channels.

Physiol Res. 59(6):927-35, 2010

IF = 1.653

2009

Grycova L. - Sklenovsky P. - Lansky Z. - Janovska M. - Otyepka M. - Amler E. - Teisinger J. - Kubala M.

ATP and magnesium drive conformational changes of the Na+/K+-ATPase cytoplasmic headpiece.

Biochimica Et Biophysica Acta-Biomembranes, 1788(5), 1081-1091, 2009

IF = 4.18

Benedikt J. - Samad A. - Ettrich R. - Teisinger J. - Vlachova V.

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

Biochimica Et Biophysica Acta-Molecular Cell Research, 1793(7), 1279-1288, 2009

IF = 4.893

Kubala M. - Grycova L. - Lansky Z. - Sklenovsky P. - Janovska M. - Otyepka M. - Teisinger J.

Changes in electrostatic surface potential of Na+/K+-ATPase cytoplasmic headpiece induced by cytoplasmic ligand(s) binding.

Biophysical Journal, 97(6), 1756-1764, 2009

IF = 4.683

Silhan J. - Vacha P. - Strnadova P. - Vecer J. - Herman P. - Sulc M. - Teisinger J. - Obsilova V. - Obsil T.

14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4.

Journal of Biological Chemistry, 284(29), 19349-19360, 2009

IF = 5.52

Jindrichova M. - Vavra V. - Obsil T. - Stojilkovic S. S. - Zemkova H.

Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors.

Journal of Neurochemistry, 109(3), 923-934, 2009

IF = 4.5

2008

Grycova L. - Lansky Z. - Friedlova E. - Obsilova V. - Janouskova H. - Obsil T. - Teisinger J.

Ionic interactions are essential for TRPV1 C-terminus binding to calmodulin.

Biochemical and Biophysical Research Communications, 375(4), 680-683, 2008

IF = 2.648

Obsilova V. - Nedbalkova E. - Silhan J. - Boura E. - Herman P. - Vecer J. - Sulc M. - Teisinger J. - Dyda F. - Obsil T.

The 14-3-3 protein affects the conformation of the regulatory domain of human tyrosine hydroxylase.

Biochemistry, 47(6), 1768-1777, 2008

IF = 3.379

Mazna P. - Grycova L. - Balik A. - Zemkova H. - Friedlova E. - Obsilova V. - Obsil T. - Teisinger J.

The role of proline residues in the structure and function of human MT2 melatonin receptor

Journal of Pineal Research, 45(4), 361-372, 2008

IF = 5.056

Obsil T. - Obsilova V.

Structure/function relationships underlying regulation of FOXO transcription factors.

Oncogene, 27(16), 2263-2275, 2008

IF = 7.216

Jelinkova I. - Vavra V. - Jindrichova M. - Obsil T. - Zemkova H.W. - Zemkova H. - Stojilkovic S. S.

Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectin.

Pflügers Archiv, 465(5), 939-950, 2008

IF = 3.526

Obsilova V, Silhan J, Boura E, Teisinger J, Obsil T.

14-3-3 proteins: a family of versatile molecular regulators.

Physiol Res. 57 Suppl 3:S11-21, 2008. Review.

IF = 1.653

Drastichova Z. - Bourova L. - Lisy V. - Hejnova L. - Rudajev V. - Stohr J. - Durchankova D. - Ostasov P. - Teisinger J. - Soukup T. - Novotny J. - Svoboda P.

Subcellular redistribution of trimeric G-proteins--potential mechanism of desensitization of hormone response: internalization, solubilization, down-regulation.

Physiological Research, 57, S1-S10, 2008

IF = 1.653

2007

Grycova L. - Lansky Z. - Friedlova E. - Vlachova V. - Kubala M. - Obsilova V. - Obsil T. - Teisinger J.

ATP binding site on the C-terminus of the vanilloid receptor.

Archives of Biochemistry and Biophysics, 465(2), 389-398, 2007

IF = 2.578

Boura E. - Silhan J. - Herman P. - Vecer J. - Teisinger J. - Obsilova V. - Obsil T.

Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding.

Journal of Biological Chemistry, 282(11), 8265-8275, 2007

IF = 5.581

Benedikt J. - Teisinger J. - Vyklicky ml. L. - Vlachova V.

Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.

Journal of Neurochemistry, 100(1), 211-224, 2007

IF = 4.451

Zemkova H. - Yan Z. - Liang Z. - Jelinkova I. - Tomic M. - Stojilkovic S. S.

Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.

Journal of Neurochemistry, 102(4), 1139-1150, 2007

IF = 4.451

Susankova K. - Ettrich R. - Vyklicky st. L. - Teisinger J. - Vlachova V.

Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1).

Journal of Neuroscience, 27(28), 7578-7585, 2007

IF = 7.49

Novakova-Tousova K. - Vyklicky st. L. - Susankova K. - Benedikt J. - Samad A. - Teisinger J. - Vlachova V.

Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

Neuroscience, 149(1), 144-154, 2007

IF = 3.352

2006

Jelinkova I. - Yan Z. - Liang Z. - Moonat S. - Teisinger J. - Stojilkovic S. S. - Zemkova H.

Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation.

Biochemical and Biophysical Research Communications, 349(2), 619-625, 2006

IF = 2.855

Susankova K. - Tousova K. - Vyklicky st. L. - Teisinger J. - Vlachova V.

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.

Molecular Pharmacology, 70(1), 383-394, 2006

IF = 4.469

2005

Mazna P. - Berka K. - Jelinkova I. - Balik A. - Svoboda P. - Obsilova V. - Obsil T. - Teisinger J.

Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7.

Biochemical and Biophysical Research Communications, 332(3), 726-734, 2005

IF = 3

Obsilova V. - Vecer J. - Herman P. - Pabianova A. - Sulc M. - Teisinger J. - Boura E. - Obsil T.

14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.

Biochemistry, 44(34), 11608-11617, 2005

IF = 3.848

2004

Lansky Z. - Kubala M. - Ettrich R. - Kuty M. - Plasek J. - Teisinger J. - Schoner W. - Amler E.

The hydrogen bonds between Arg423 and Glu472 and other key residues, Asp443, Ser477, and Pro489, are responsible for the formation and a different positioning of TNP-ATP and ATP within the nucleotide-binding site of Na(+)/K(+)-ATPase.

Biochemistry, 43(26), 8303-8311, 2004

IF = 4.008

Obsilova V. - Herman P. - Vecer J. - Sulc M. - Teisinger J. - Obsil T.

14-3-3zeta C-terminal stretch changes its conformation upon ligand binding and phosphorylation at Thr232.

Journal of Biological Chemistry, 279(6), 4531-4540, 2004

IF = 6.355

Silhan J. - Obsilova V. - Vecer J. - Herman P. - Sulc M. - Teisinger J. - Obsil T.

14-3-3 protein C-terminal stretch occupies ligand binding groove and is displaced by phosphopeptide binding.

Journal of Biological Chemistry, 279(47), 49113-49119, 2004

IF = 6.355

Mazna P. - Obsilova V. - Jelinkova I. - Balik A. - Berka K. - Sovova Z. - Ettrich R. - Svoboda P. - Obsil T. - Teisinger J.

Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding.

Journal of Neurochemistry, 91(4), 836-842, 2004

IF = 4.824

Tousova K. - Susankova K. - Teisinger J. - Vyklicky st. L. - Vlachova V.

Oxidizing reagent copper-o-phenanthroline is an open channel blocker of the vanilloid receptor TRPV1.

Neuropharmacology, 47(2), 273-285, 2004

IF = 3.734

Kubala M. - Obsil T. - Obsilova V. - Lansky Z. - Amler E.

Protein modeling combined with spectroscopic techniques: an attractive quick alternative to obtain structural information.

Physiological Research, 53(Suppl. 1), S187-S197, 2004

IF = 1.14