“CD8+ T cells in infection: Orchestration of the effector and memory fates”

In infection, naive CD8+ T cells differentiate into short-lived effector cells, which provide immediate protection against the pathogen, and long-lived memory cells, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families, we show which factors drive the effector versus memory cell fate decision.