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Seminář Veronika Niederlová
Seminář Veronika Niederlová
“CD8+ T cells in infection: Orchestration of the effector and memory fates” In infection, naive CD8+ T cells differentiate into short-lived effector cells, which provide immediate protection against the pathogen, and long-lived memory cells, which retain immunological information long after pathogen clearance. Using single-cell multiomics techniques and in vivo tracking of individual clonal families, we show…
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Seminář Viktor Bugajev
Seminář Viktor Bugajev
“Multiple Layers of Control in Early Sphingolipid Biosynthesis” Sphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and is tightly regulated at the level of the serine palmitoyltransferase (SPT) complex. ORMDL proteins are established canonical negative regulators of SPT activity,…
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Seminář Anna Koslová
Seminář Anna Koslová
“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” Viruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs), many of which appear intact and may represent functional viruses. Some EVEs are…
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Seminář Hanna-Mari Baldauf
Seminář Hanna-Mari Baldauf
“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV, which is a long standing interest in the lab. We use virological, cellular, biochemical, and evolutionary approaches to decipher motifs/pathways that…
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Seminář Lorena Arranz
Seminář Lorena Arranz
“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche.…
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