Akce

Modeling human early pregnancy with stem cells” The blastocyst is the early mammalian organism before implantation in the uterus. We have promoted the self-organization of stem cells into models of mouse and human blastocysts, which we have named blastoids (Nature 2018, Nature 2021). Blastoids are morphologically and transcriptionally similar to the blastocyst and contain analogs…
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“Infections and hematopoietic stem cells: how do they communicate?” Infections are primarily cleared by immune cells in our bodies. However, we observed that the most immature hematopoietic stem cells also contribute to this process. In this lecture, we will report on the mechanisms that activate an hematopoietic stem cell during infection and the cellular adaptations that…
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Speaker: Martina Rauner, Technische Universität Dresden, Germany

“Tipping the Lipid Scales: Negative Feedback Regulation via ORMDLs Protein Degradation Ensures Sphingolipid Homeostasis” Sphingolipids are essential lipid molecules that contribute to cellular structure and signaling. Their de novo synthesis is initiated in the endoplasmic reticulum (ER) and catalyzed by the multimeric serine palmitoyltransferase (SPT) complex. The ER-resident ORMDL proteins are well-established regulators of sphingolipid…
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“RNA cap methylation in poxviruses and coronavirus – differences and similarities” RNA methyltransferases (MTases) are responsible for synthesizing the 5' RNA cap, which plays a crucial role in RNA stability and efficient translation. Over the past two years, both our research team and others have developed numerous inhibitors targeting coronaviral MTases. Through our efforts, we…
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