Single-cell RNA sequencing (scRNA-seq) allows researchers to study gene expression at the level of individual cells. This approach can, for example, help to identify different cell populations in a complex sample and describe their expression patterns. To generate and analyse scRNA-seq data, several methods are available, all with their strengths and weaknesses depending on the… Více
Doc. Ing. Tomáš Čajka Ph.D., Fyziologický ústav AV ČR, bude zajišťovat 21 th Metodologický seminář Krč – Biocev na téma: „Metabolomics and lipidomics: platforms, pitfalls, and practical tips“, který se bude konat 1.12.2025 od 15,00 hodin v Kinosále FGÚ. Anotace: Metabolomics and lipidomics are rapidly advancing fields that have transformed our understanding of biological processes at… Více
“Nuclear myosin 1 – from gene to function” Mitochondria play a vital role in cellular metabolism by generating energy through oxidative phosphorylation (OXPHOS) in most somatic cells. However, highly proliferative, undifferentiated pluripotent stem cells and cancer cells mainly rely on aerobic glycolysis for energy production. Recently, we reported that nuclear myosin 1 (NM1) functions as… Více
“Enigmatic germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes” Centromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore explain the unusual mitotic and meiotic behaviour of certain chromosomes, such as the germline-restricted chromosome (GRC) of songbirds. This chromosome is eliminated from somatic cells… Více
“ALDH1A1 inhibition as a therapeutic target in Acute Myeloid Leukemia” Acute Myeloid Leukemia (AML) is a hematological malignancy leading to differentiation arrest of the myeloid compartment in the bone marrow. It is reported that high levels of ALDH1A1 inhibition promote chemoresistance in AML. Therefore, in my project we are studying the role of ALDH1A1 inhibition… Více