Akce

Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. Jedním z kandidátů na předsedu AV ČR je prof. RNDr. Libor Grubhoffer, CSc., dr. h. c. mult.,…
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“Viral Influencers: How endogenous retroviruses regulate innate immunity and senescence” The human genome harbors a significant number of endogenous retroviral elements, remnants of ancient viral integration events. While often referred to as “genomic fossils" and “dark matter of the genome” many of these elements function as promoters or enhancers for cellular genes. This presentation will…
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“Impact of Medulloblastoma-Derived Extracellular Vesicles on Neural Stem/Progenitor Cells” Medulloblastoma is the most common malignant brain tumor in children. Recent advances in understanding its genetic and molecular heterogeneity have uncovered at least four distinct subgroups, each characterized by unique transcriptional profiles, DNA alterations and clinical outcomes. Extracellular vesicle secretion has emerged as a critical mediator…
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This course will provide valuable insights and practical skills in the rapidly evolving field of single cell analyses and spatial transcriptomics. With a maximum of 10 participants, you’ll receive personalized attention and the opportunity to engage deeply with the subject. If you’re interested in joining us, please respond via email to sindelka@ibt.cas.cz as soon as…
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Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation Lecturer: Satyendra Mondal, MSc. / Department of Functional Organisation of Biomembranes Annotation: The regulation of eukaryotic gene expression via mRNA degradation is an evolutionarily conserved process, with the 5'-3' exoribonuclease 1 (Xrn1) playing a pivotal role. In yeast, following the depletion of fermentable carbon source,…
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Ondřej Kuda, Laboratory of Metabolism of Bioactive Lipids, IPHYS

“Unravelling autoimmunity in Addison’s disease using a new mouse model” Autoimmune Addison's disease is a disorder targeting steroid-producing cells in the adrenal glands. Due to the lack of suitable animal models, the immune mechanisms underlying adrenal destruction remain largely unknown. To address this, we developed the first defined mouse model of experimental autoimmune adrenalitis by…
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Olga Zimmermannová, Laboratory of Membrane Transport, IPHYS.

Prohlídka laboratoří, ukázky experimentů v oblasti molekulární genetiky, imunologie, buněčné biologie, virologie, prohlídka posterů a diskuse k vybraným tématům.

“Homologous Recombination - From Repair of DSBs to Processing Stalled Replication Forks and Human Diseases” Our lab focuses on the mechanisms ensuring accurate DNA replication and the role of homologous recombination (HR) in preventing genome instability. We investigate how endogenous hard-to-replicate regions, G-quadruplexes (G4) and R-loops, impact replication and contribute to disease development. A key…
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Max Planck Institute for Medical Research, Heidelberg “Viruses of unicellular eukaryotes: A tale of giants and hyperparasites” Viruses of protists play important roles in ecology and evolution by influencing microbial population dynamics and shaping eukaryotic genomes by endogenization. Of particular interest are complex DNA viruses whose particle and genome sizes overlap with those of bacteria.…
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