“Regulation of microtubule organization in glioblastoma cells by GIT2 phosphorylation” Glioblastoma, the most aggressive common type of brain cancer in humans, carries a very poor prognosis for patient survival. Microtubules are critical for cell division and mesenchymal migration, processes that strongly influence tumor viability and invasiveness. While the reorganization of highly dynamic microtubules is central… Více
“How Cells Keep DNA Replication in Check” Accurate DNA replication is the foundation of genome stability and cell survival. Our study uncovers a key “gatekeeper” complex that ensures the molecular machinery starting DNA replication is properly assembled and regulated. When this control breaks down, replication becomes uncoordinated, leading to stress, genetic instability, and changes often… Více
Department of Microbiology, College of Medicine, Yonsei University, Seoul, South Korea “Intrinsic mechanisms governing B cell discrimination between self and non-self antigens”
Dear colleagues and friends, This year marks the 100th anniversary of the birth of Prof. Milan Hašek (October 4, 1925), a giant of Czech immunology. He was not only an outstanding scientist, immunologist, biologist, and physician, but also an inspiring mentor to an entire generation of researchers, many of whom emigrated after 1968 and became… Více
“Ontogeny of zebrafish erythropoietic waves” Hematopoiesis is the process of blood formation, which occurs in multiple waves during vertebrate development. In zebrafish, the first wave initiates before 24 hours post-fertilization with the generation of primitive myeloid cells from cephalic mesoderm and primitive erythrocytes in the intermediate cell mass. The first definitive wave is transient, and… Více