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„How MHC I Peptides Are Generated for Viral and Cancer Immunosurveillance“ The talk focuses on peptide generation from DRiPs (defective ribosomal products), ribosomal generated polypeptides that don’t achieve folded stable forms and are proteolytically converted into peptides presented by MHC I molecules for CD8+ T cell immunosurveillance. Influenza A virus DRiPs will occupy center stage.…
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“How molecular motors drive the motility of cilia and flagella” Cilia and flagella are thin, rod-like organelles whose snake-like beating patterns drive cells through fluids and move fluids across cellular surfaces. They play essential roles in locomotion, sensory reception, and signaling. The core structure within the cilium, known as the axoneme, consists of nine pairs…
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Dear all, we would like to invite you to the seminar as part of the "BIOCEV-Krč  Methodological Seminar": Topic: "CAMPUS ANIMAL FACILITY" Seminar program: Animal Facility FGÚ: Martin Blažka Animal Facility MBÚ: Alexandra Bartelik / Martin Schwarzer Animal Facility ÚŽFG: Jiří Klíma Animal Facility ÚEM: Andrej Litvinec Animal Facility ÚMG: Libor Kopkan / Jan Honetschläger The…
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“An Intimate Dance of Two: Revealing Membrane Morphology in Early Immunological Synapse” T cells are central to how the immune system recognizes and responds to threats, yet the physical organization of their surface during activation is not fully understood. In this lecture, we use advanced imaging techniques to explore how T cells interact with antigen-presenting…
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“Primary Cilia in Bone Marrow Niche Regulation” Primary cilia are small sensory organelles that regulate cellular signaling, but their role in the bone marrow mesenchymal stromal cell (MSC) niche is still not well understood. Here, we show that MSCs possess primary cilia both in vivo and in vitro and are mainly located around blood vessels…
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