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Single-cell RNA sequencing (scRNA-seq) allows researchers to study gene expression at the level of individual cells. This approach can, for example, help to identify different cell populations in a complex…
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Doc. Ing. Tomáš Čajka Ph.D., Fyziologický ústav AV ČR, bude zajišťovat  21 th Metodologický seminář Krč – Biocev na téma: „Metabolomics and lipidomics: platforms, pitfalls, and practical tips“, který se…
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“Nuclear myosin 1 – from gene to function” Mitochondria play a vital role in cellular metabolism by generating energy through oxidative phosphorylation (OXPHOS) in most somatic cells. However, highly proliferative,…
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“Enigmatic germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes” Centromeres are an important part of chromosomes which direct chromosome segregation during cell division. Their modifications can therefore…
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“ALDH1A1 inhibition as a therapeutic target in Acute Myeloid Leukemia” Acute Myeloid Leukemia (AML) is a hematological malignancy leading to differentiation arrest of the myeloid compartment in the bone marrow.…
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“CD8+ T cells in infection: Orchestration of the effector and memory fates” In infection, naive CD8+ T cells differentiate into short-lived effector cells, which provide immediate protection against the pathogen, and…
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“Multiple Layers of Control in Early Sphingolipid Biosynthesis” Sphingolipids are fundamental components of cellular membranes and key mediators of intracellular signaling. Their de novo synthesis is initiated in the endoplasmic…
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“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” Viruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through…
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“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a…
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“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation,…
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“Harnessing TCR Discoveries for the Next Generation of Immunotherapies” Recent advances in synthetic immunology and CAR T cell engineering have highlighted the critical importance of signaling diversity for optimizing anti-tumor…
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“NG2-lineage cell plasticity in ischemic brain repair: Roles of Wnt signaling” Focal cerebral ischemia (FCI) leads to neuronal loss followed by extensive tissue remodeling, in which glial and vascular cell populations…
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