Akce

“Investigating the Impact of Cullin-Dependent Degradation on Protein Homeostasis” Cullin-dependent ligases (CRLs) regulate cellular homeostasis by targeting proteins for degradation. Mutations and alterations in the CRL substrate receptor FBXO38 have been linked to distal muscular atrophy, chronic obstructive pulmonary disease, and gender dysphoria. In our previous research, we demonstrated that FBXO38 controls centromeric chromatin density…
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Dear colleagues, We would like to invite you to the 17th IMG PhD conference that will be on the 11th of October. This year we will be hosting two international speakers: Mileidys Perez Alea, who will have a talk about ¨How to build a Start-up¨ and Elodie Chabrol, who will be talking about the world…
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Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. Jedním z kandidátů na předsedu AV ČR je prof. RNDr. Radomír Pánek, Ph.D., který představí zaměstnancům krčského…
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Martin Rossmeisl, Laborator of Adipose Tissue Biology, IPHYS

Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. Jedním z kandidátů na předsedu AV ČR je prof. RNDr. Libor Grubhoffer, CSc., dr. h. c. mult.,…
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“Viral Influencers: How endogenous retroviruses regulate innate immunity and senescence” The human genome harbors a significant number of endogenous retroviral elements, remnants of ancient viral integration events. While often referred to as “genomic fossils" and “dark matter of the genome” many of these elements function as promoters or enhancers for cellular genes. This presentation will…
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“Impact of Medulloblastoma-Derived Extracellular Vesicles on Neural Stem/Progenitor Cells” Medulloblastoma is the most common malignant brain tumor in children. Recent advances in understanding its genetic and molecular heterogeneity have uncovered at least four distinct subgroups, each characterized by unique transcriptional profiles, DNA alterations and clinical outcomes. Extracellular vesicle secretion has emerged as a critical mediator…
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This course will provide valuable insights and practical skills in the rapidly evolving field of single cell analyses and spatial transcriptomics. With a maximum of 10 participants, you’ll receive personalized attention and the opportunity to engage deeply with the subject. If you’re interested in joining us, please respond via email to sindelka@ibt.cas.cz as soon as…
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Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation Lecturer: Satyendra Mondal, MSc. / Department of Functional Organisation of Biomembranes Annotation: The regulation of eukaryotic gene expression via mRNA degradation is an evolutionarily conserved process, with the 5'-3' exoribonuclease 1 (Xrn1) playing a pivotal role. In yeast, following the depletion of fermentable carbon source,…
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Ondřej Kuda, Laboratory of Metabolism of Bioactive Lipids, IPHYS

“Unravelling autoimmunity in Addison’s disease using a new mouse model” Autoimmune Addison's disease is a disorder targeting steroid-producing cells in the adrenal glands. Due to the lack of suitable animal models, the immune mechanisms underlying adrenal destruction remain largely unknown. To address this, we developed the first defined mouse model of experimental autoimmune adrenalitis by…
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