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“Integration and reactivation of endogenous DNA viruses in unicellular eukaryotes” Viruses infecting protists play important ecological and evolutionary roles by modulating microbial population dynamics and contributing to genome evolution through endogenization. Protist genomes contain tens to thousands of endogenous viral elements (EVEs), many of which appear intact and may represent functional viruses. Some EVEs are…
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“From virus-host interactions to a novel protein delivery tool” The VIIRAL lab has advanced the understanding of species-specific virus-host interactions against retroviruses. This advancement facilitates now the development of a rabbit model against HIV, which is a long standing interest in the lab. We use virological, cellular, biochemical, and evolutionary approaches to decipher motifs/pathways that…
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“Therapeutic targeting of stem cells and their niches in myeloid malignancies” Our research group “Stem Cells, Ageing and Cancer” aims at providing insights into mechanisms of hematopoietic stem cell malignant transformation, including interactions of this cell with its surrounding microenvironment, and a focus on inflammation, signaling oncometabolites and various cellular components of the stem cell niche.…
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“Harnessing TCR Discoveries for the Next Generation of Immunotherapies” Recent advances in synthetic immunology and CAR T cell engineering have highlighted the critical importance of signaling diversity for optimizing anti-tumor responses. Our work outlines the design of innovative cell-based cancer immunotherapies rooted in a molecular understanding of T cell activation via the T cell receptor…
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