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“A hidden layer of chromatin regulation in neurological disease” Genome stability and DNA repair are essential for human health. ADP-ribosylation is a key post-translational modification in the DNA damage response, regulated by PARP enzymes. Our research focuses on ARH3, an enzyme that removes mono-ADP-ribose from proteins, as its deficiency is linked to rare neurological disease.…
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“Mechanisms of MICAL regulation in actin filament disassembly” Actin oxidation at specific methionine residues is a distinctive mechanism that drives actin filament disassembly. This process is mediated by the cytoskeletal effector MICAL, which selectively associates with and oxidizes actin filaments, thereby promoting their disassembly. MICAL-dependent actin oxidation is essential for axon guidance and also contributes…
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Learn practical workflows for image segmentation, cell tracking, and denoising using modern deep-learning tools (StarDist, Cellpose, Omnipose, Noise2Void, DeepImageJ, TrackMate, Delta2, ZeroCostDL4MIc, Zeiss arivis Cloud). More information & registration: https://course.img.cas.cz/aist/ Registration deadline: May 4 Best regards, Martin Čapek, Michaela Blažíková, Jan Valečka and Pavel Krist (Zeiss)

Dear colleagues,   we would like to announce the upcoming practical course Super-Resolution in Light Microscopy (SLM 2026), which will take place June 8–10, 2026 at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague.   Some of you may know our EMBO Practical Course on Super-Resolution Microscopy, which we bi-annually…
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