We are pleased to announce the annual mini-symposium BIOCEV Regeneration IV, which will be held on November 26th, 2024, in BIOCEV Centre, Vestec. BIOCEV Regeneration is an annual open one-day mini-symposium that brings together researchers from different fields of biomedicine, from regenerative medicine and tissue engineering to cancer research, drug discovery, and cryobiology. This year,… Více
Due to reaching capacity for in-person participation, registration is now only available for online attendance. Thank you for your understanding. Basic information The course is tailored to users already familiar with the basics of image processing. It will be focused on automatization, high throughput and basic scripting. Course participants will learn how to create and… Více
“CRL4COP1 ubiquitination complex as a balancer of early odontogenesis” Cullin-RING ubiquitin ligase (CRL) complexes have been heavily studied in connection to cancer progression but there is limited evidence about their physiological roles. One of the exceptions is disruption of limb development by thalidomide induced by inhibition of CRL4 complex via regulation of Fgf8 (Ito et… Více
The course is very practically-oriented, theoretical lectures are followed by 6 hours of hands-on session every day in small groups. You will learn widefield, confocal, and advanced methods including super-resolution, photomanipulation, and FLIM. You will have a chance to work on high-end microscopes and compare wide variety of approaches and instrumentation. For detailed program and… Více
“Every stick has two ends – Using high resolution imaging to characterize both ends of the eukaryotic flagellum” The eukaryotic flagellum is important for cell motility. The microtubule-based axoneme generating the flagellar beating has been extensively studied. However, additional structures are associated with the proximal and distal end of the flagellum, with their composition and… Více
The human eye is our primary tool for interpreting images, so scientific images should be adjusted with this perception in mind. However, display and print transfer characteristics often degrade images, making them differ from reality. This course offers a unique approach, focusing on preparing image data for presentation. We’ll cover essential topics like gamma correction… Více
“Quality control in snRNP biogenesis” Before being assembled into spliceosomes, small nuclear ribonucleoprotein particles (snRNPs) undergo a complex and regulated maturation pathway. Cajal bodies (CBs) have been shown to monitor the final stage of this process by sequestering immature or misassembled particles through a yet unknown quality control mechanism. Here, we have identified coilin, a… Více
Lukáš Chmátal, Ph.D., Whitehead Institute for Biomedical Research, MIT, USA Heart disease is the leading cause of death worldwide, but its effects are far from uniform. Men and women experience striking differences in symptoms, prevalence, and outcomes – yet the molecular mechanisms underlying these differences remain poorly understood. In this lecture, I will reveal how… Více
“Structural basis of MICAL autoinhibition and activation” In this talk, we will explore the role of MICAL proteins in cellular dynamics, focusing on their ability to disassemble actin filaments and their implications for processes like axon guidance, cytokinesis, and cell morphology. We will present our recent findings based on the cryoEM structure of human MICAL1,… Více