Akce

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation Lecturer: Satyendra Mondal, MSc. / Department of Functional Organisation of Biomembranes Annotation: The regulation of eukaryotic gene expression via mRNA degradation is an evolutionarily conserved process, with the 5'-3' exoribonuclease 1 (Xrn1) playing a pivotal role. In yeast, following the depletion of fermentable carbon source,…
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Ondřej Kuda, Laboratory of Metabolism of Bioactive Lipids, IPHYS

“Unravelling autoimmunity in Addison’s disease using a new mouse model” Autoimmune Addison's disease is a disorder targeting steroid-producing cells in the adrenal glands. Due to the lack of suitable animal models, the immune mechanisms underlying adrenal destruction remain largely unknown. To address this, we developed the first defined mouse model of experimental autoimmune adrenalitis by…
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Olga Zimmermannová, Laboratory of Membrane Transport, IPHYS.

Prohlídka laboratoří, ukázky experimentů v oblasti molekulární genetiky, imunologie, buněčné biologie, virologie, prohlídka posterů a diskuse k vybraným tématům.

“Homologous Recombination - From Repair of DSBs to Processing Stalled Replication Forks and Human Diseases” Our lab focuses on the mechanisms ensuring accurate DNA replication and the role of homologous recombination (HR) in preventing genome instability. We investigate how endogenous hard-to-replicate regions, G-quadruplexes (G4) and R-loops, impact replication and contribute to disease development. A key…
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Max Planck Institute for Medical Research, Heidelberg “Viruses of unicellular eukaryotes: A tale of giants and hyperparasites” Viruses of protists play important roles in ecology and evolution by influencing microbial population dynamics and shaping eukaryotic genomes by endogenization. Of particular interest are complex DNA viruses whose particle and genome sizes overlap with those of bacteria.…
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BBMRI.cz - The Network of Czech Biobanks: Access to human samples

We are pleased to announce the annual mini-symposium BIOCEV Regeneration IV, which will be held on November 26th, 2024, in BIOCEV Centre, Vestec. BIOCEV Regeneration is an annual open one-day mini-symposium that brings together researchers from different fields of biomedicine, from regenerative medicine and tissue engineering to cancer research, drug discovery, and cryobiology. This year,…
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“CRL4COP1 ubiquitination complex as a balancer of early odontogenesis” Cullin-RING ubiquitin ligase (CRL) complexes have been heavily studied in connection to cancer progression but there is limited evidence about their physiological roles. One of the exceptions is disruption of limb development by thalidomide induced by inhibition of CRL4 complex via regulation of Fgf8 (Ito et…
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