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“Life Through Colors: Single-cell fluorescence-based reporter system for monitoring gene expression” The presentation will depict a long journey from decision to actual making a novel reporter system for RNA silencing, which could also be adopted for studying other mechanisms manipulating gene expression. This development lead to production of two types of triple-color reporter HeLa lines…
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“Analysis of a novel chicken Pax6 mutant”  Pax6 is known as the "master control gene" for eye formation, playing a crucial role in the development of the lens, retina, and other ocular structures. It drives the formation of the eye field, initiates lens differentiation, and helps establish the retina—all vital for vision. While the role of Pax6 in…
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“Deciphering PNKP Functions in Neurological Disorders” Hereditary mutations in polynucleotide kinase-phosphatase (PNKP), a key enzyme in DNA strand break repair, result in a broad spectrum of neurological disorders, ranging from mild neurodegeneration to severe neurodevelopmental defects. PNKP has dual phosphatase and kinase activities essential for DNA break repair, but their specific contributions to preventing neuropathology…
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“Preclinical development of IL-15-based immunocytokine SOT201 and antibody-drug conjugate SOT106 for treatment of solid tumors” SOT201 is a novel cis-acting immunocytokine consisting of an antibody against PD-1 genetically fused to a sushi+ domain of IL-15Ra and IL-15 mutein. SOT201 targets PD-1+ TILs with a balanced cytokine potency to revive exhausted T cells in tumor microenvironment.…
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Dear friends and colleagues, it is my pleasure to invite you to a special seminar given by                       Prof. Sophie Janssens, PhD. VIB-UGent Center for Inflammation Research, Belgium Title: The unfolded protein sensor IRE1 as a regulator of homeostatic dendritic cell maturation   Monday, April 28, 2025 at 10 am, in Hasek's lecture hall, Institute…
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"SHOULD CANCER PATIENTS EAT DIFFERENTLY? Metabolomics-guided dietary intervention for optimal clinical use of anti-cancer MCL1 inhibitors.” Diet is the major source of nutrients for tumors. However, dietary interventions in cancer patients lack personalization. One of our active research areas is aimed at tailoring metabolomics-guided strategies to enhance the therapeutic effects of anti-cancer agents and/or ameliorate…
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