“Human Endogenous Retroviruses: Role in Negative Selection of T cells in the Thymus and Pathogenesis of Psoriasis” Our research elucidates the role of human endogenous retroviruses (HERVs) in biological processes related to T cell immunity, autoimmunity, and the pathogenesis of psoriasis. HERVs are ancient viral elements integrated into the human genome. While most of these elements… Více
Single-particle tracking of NMDA receptors at hippocampal synapses Lecturer: Mgr. Petra Zahumenská / Department of Neurochemistry Annotation: N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for excitatory neurotransmission. These heterotetrameric complexes consist of two obligatory GluN1 subunits combined with two GluN2 (GluN2A-GluN2D) or GluN3 (GluN3A-GluN3B) subunits. The surface expression and subtype composition of NMDARs are… Více
“Investigating the Impact of Cullin-Dependent Degradation on Protein Homeostasis” Cullin-dependent ligases (CRLs) regulate cellular homeostasis by targeting proteins for degradation. Mutations and alterations in the CRL substrate receptor FBXO38 have been linked to distal muscular atrophy, chronic obstructive pulmonary disease, and gender dysphoria. In our previous research, we demonstrated that FBXO38 controls centromeric chromatin density… Více
Dear colleagues, We would like to invite you to the 17th IMG PhD conference that will be on the 11th of October. This year we will be hosting two international speakers: Mileidys Perez Alea, who will have a talk about ¨How to build a Start-up¨ and Elodie Chabrol, who will be talking about the world… Více
Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. Jedním z kandidátů na předsedu AV ČR je prof. RNDr. Radomír Pánek, Ph.D., který představí zaměstnancům krčského… Více
Dne 24. 3. 2025 skončí druhé čtyřleté období ve funkci předsedkyně AV ČR prof. RNDr. Evě Zažímalové, CSc. Volba kandidátky/kandidáta na předsedu AV ČR pro následné funkční období proběhne na zasedání sněmu AV ČR dne 10. 12. 2024. Jedním z kandidátů na předsedu AV ČR je prof. RNDr. Libor Grubhoffer, CSc., dr. h. c. mult.,… Více
“Viral Influencers: How endogenous retroviruses regulate innate immunity and senescence” The human genome harbors a significant number of endogenous retroviral elements, remnants of ancient viral integration events. While often referred to as “genomic fossils" and “dark matter of the genome” many of these elements function as promoters or enhancers for cellular genes. This presentation will… Více
“Impact of Medulloblastoma-Derived Extracellular Vesicles on Neural Stem/Progenitor Cells” Medulloblastoma is the most common malignant brain tumor in children. Recent advances in understanding its genetic and molecular heterogeneity have uncovered at least four distinct subgroups, each characterized by unique transcriptional profiles, DNA alterations and clinical outcomes. Extracellular vesicle secretion has emerged as a critical mediator… Více